摘要
目的:研究我院药品不良反应报告的特点,以期对临床安全用药提供参考。方法:收集我院上报国家药品不良反应网络的报告250例,对报告来源、ADR表现、怀疑药物、潜伏期、类型、识别方式等进行统计分析。结果:药师报告占67.2%,高于医生(9.2%)和护士(23.6%);"新的"报告15例(6.0%),"严重的"报告11例(4.4%)。皮肤及其附件反应占63.2%,居于首位,胃肠系统反应占13.0%,列第二位。从ADR涉及的怀疑药物统计,全身用抗菌药物列于首位,占48.8%,眼科用药列于第二位17.7%,主要为眼科诊断试剂。具有药源性特征强、潜伏期短以及背景发生率低的ADR报告比例列于前位,更容易被识别上报。结论:进一步加强医务人员的对于ADR知识的培训,并结合我院的专科特点,积极探索ADR发掘的途径,了解ADR发生的特点,提高对ADR识别、判断能力,从而加强ADR监测和临床用药安全。
Objective：To characterize the adverse drug reactions （ADR） reports in EYE ＆ ENT hospital, and to provide theoretical reference for clinical safe medication. Methods：250 ADR cases reported to Nati,mal ADR Monitoring Center were analyzed statistically in the aspects of report source, manifestations of ADRs, suspected drugs, types of ADRs, latency and recognition manners of ADRs. Results： In the aspect of report source, the proportion of the ADR reports from pharmacists was 67.2% , higher than that from doctors （9.2%） and nurses （23.6%）. 15 new ADR cases（6% ） and 11 severe ADR cases（4.4% ） were reported. In the aspects of manifestations of ADRs, the reports on skin and its appendages ranked first （63.2%）, and the reports on gastrointestinal system ranked second （13.0%）. In the aspects of suspected drug, antibacterial drugs listed in the first place （48.8%） , and ophthalmic drugs listed in the second place （17.7%） , most of them were ophthalmology diagnosis reagent. In the aspects of type of ADRs, type B ADRs accounted for 77.6%, higher than type A ADRs （22.4%）. The ADRs cases which had strong characteristics, short latency and low background incidence were more likely to be found and reported. Conclusion： Considering the special features of our hospital, we should take further efforts to solidate the training of medical staff, actively expand the ways of ADR data mining, understand the characteristics and patterns of ADR, improve the ADR recognition and judgment, and thus strengthen the ADR monitoring and clinical medication safety.
出处
《药物流行病学杂志》
CAS
2014年第12期725-729,共5页
Chinese Journal of Pharmacoepidemiology
关键词
药品不良反应
监测
报告
眼耳鼻喉专科
药物安全性
Adverse drug reaction
Moruitoring
Report
EYE ＆ ENT special hospital
Drug safety
