摘要
目的：比较钙泊三醇倍他米松和卤米松软膏外用治疗白癜风患者的临床疗效和安全性的差异。方法：自身左右对照临床试验研究，入组68例寻常型白癜风患者，均有左右对称皮损。实验侧外用钙泊三醇倍他米松软膏，1次／日，对照侧外用卤米松软膏，1次／日，疗程为3月，同时可采用口服中成药物和光疗等治疗。于首次用药后第12周观察临床疗效及不良反应。结果：治疗12周后实验侧白斑平均复色率15．51％±0．13％，对照侧的复色率为12．86％±0．22％，两组比较，T=2．013，P〈0．05，具有显著性统计学差异。实验侧不良反应发生率为1．4％±0．02％，右侧不良反应发生率2．9％±0．01％，两组间差异具有统计学意义，x2=4．345，P〈0．05。药物不良反应主要为与皮肤有关的轻中度反应如瘙痒、红斑等刺激反应，均无皮肤萎缩、继发感染等反应。结论：钙泊三醇倍他米松软膏治疗寻常型白癜风患者的疗效优于卤米松软膏，具有起效快、疗效好和用药方便、相对安全的特点。
Objective To assess the clinical eficacy and safety of calcipotriol betam ethasone and halometasone cream in Chinese patients with stable vitiligo vulgaris. Methods In this self-controlled parallel group study. 68 vitiligo with symmetrical white macules were recruited from the out-patient clinic. The left lesions receive alcipotriol betamethasone ointment once daily in the evening, and the right lesion receive halometasone cream once daily in the morning. The safety and eficacy of the two regimens were evaluated on week 12 after the first dosage. Results Atier 12 weeks of treatment, mean repigmentation was observed in 15.51% ＋0.13%for the left lesions, 12.86%＋0.22% for the right group. There is significant difference between calcipotriol betam ethasone and halometasone cream （T=2.013,P〈0.05）. The ratio of side-effects was 1.4%＋0.02% in the calcipotriol betam ethasone group, and 2.9%＋0.01% in the halometasone cream group . Significant difference is seen among the two groups （X2=4.345, P〈0.05）. Main side adverses include mild to moderate skin reactions,such as pruritus. Conclusions Once daily calcipotriol betamethasone ointment is an effective, safe,convenient treatment with a rapid onset of action for stable vitiligo vulgaris in Chinese patients.
出处
《中国美容医学》
CAS
2012年第8期1366-1368,共3页
Chinese Journal of Aesthetic Medicine
基金
国家自然科学基金(30972642,81130032)
关键词
白癜风
钙泊三醇倍他米松
卤米松
临床疗效
vitiligo
calcipotriol betam ethasone
halometasone
clinical efficacy
