摘要
轻型创伤性颅脑损伤(mild traumatic brain injury,mTBI)是青壮年常见的一类脑功能障碍疾病,其功能损害常常伴随着白质纤维束损伤、轴突断裂水肿改变为基础的弥散性轴索损伤(diffuse axonal in-jury,DAI)而加剧。因轻、中型脑损伤或DAI损伤具有弥散性与细微性特点,常规CT及MRI检查难有阳性发现。近来临床研究发现功能磁共振成像对急性轻、中型脑损伤的诊断有很高的甄别价值。本文就功能磁共振弥散张量成像(diffuse tensor imaging,DTI)与质子磁共振波谱(1H-magnetic resonance spectroscopy,1H-MRS)技术的原理、特点及近年来在脑损伤临床及动物实验中的应用研究进行综述。
Mild traumatic brain injury （mTBI） is a common type of brain disorders among young adults. The dysfunction of the brain is often exacerbated due to diffuse axonal injury （DAI） which based on the injury of white matter fibers and axons. Since mild and moderate brain injury or DAI are diffuse and subtle, conventional CT and MRI are diffieuh to make a positive diagnosis. Recent clinical study indicated that functional magnetic resonance imaging has a high detection rate in the diagnosis of acute mild and moderate brain injury, especially the diffusion tensor imaging （DTI） and 1H-magnetic resonance spec- troscopy （1H-MRS）. This paper has reviewed the principles and characteristics of DTI and IH-MRS, and recent research in the clinical and animal experiments on brain injury.
出处
《法医学杂志》
CAS
CSCD
2012年第3期207-210,共4页
Journal of Forensic Medicine
基金
国家自然科学基金资助项目(30560041)
云南省自然科学基金项目(2008CD052)
关键词
法医学
脑损伤
综述[文献类型]
磁共振成像
弥散
质子磁共振波谱
forensic medicine
brain injuries
review[publication type]
diffusion magnetic resonance imag- ing
IH-magnetic resonance spectroscopy
