摘要
目的评价管花肉苁蓉提取物的安全性。方法清洁级SD大鼠、昆明种小鼠,分别进行急性经口毒性试验、Ames试验、小鼠骨髓嗜多染细胞微核试验、小鼠精子畸形试验及致畸试验,观察管花肉苁蓉提取物毒性、致突变及致畸作用。结果管花肉苁蓉提取物急性经口毒性试验最大耐受剂量(MTD)均>10g/kg.bw,属实际无毒物;骨髓微核试验、精子畸形试验、Ames试验表明该样品无致突变作用;致畸试验结果为阴性,无致畸作用。结论管花肉苁蓉提取物有较好的安全性,可以用于保健食品的开发。
Objective To study the safety evaluation of Cistanche tubulosa extracts. Methods Acute oral toxicity test, Ames test, microkernel test, sperm malformation test and teratogenicity test were conducted by using clean SD rats and Kunming mice. The extract toxic, mutagenic and teratogenic effects of Cistanche tubulosa were ob- served. Results Maximally tolerated dose （MTD） of the Gstanche tubulosa extracts was ）10 g/kg ~ bw in acute oral toxicity test and it belonged to actually nontoxic~ Ames test, microkernel test and sperm malformation test showed the sample was safe without mutagenesis. A negative result was obtained in teratogenicity test. The tera- togenic experimental result was negative, there was no teratogenic effects. Conclusion The extracts of Cistanche tubulosa have good safety, they can be used to develop health food.
出处
《新疆医科大学学报》
CAS
2012年第7期870-873,共4页
Journal of Xinjiang Medical University
基金
科技部国际科技合作项目(2010DFB30540)
乌鲁木齐市科技计划项目(Y111120004)
关键词
管花肉苁蓉提取物
安全性
评价
extracts of Cistanche tubulosa
safety
evaluation
