期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脱氧核糖核酸甲基化在阿尔茨海默病发病机制中的研究进展 被引量：2

原文传递
导出
摘要 阿尔茨海默病（Alzheimer’s disease，AD）是一种以进行性认知功能障碍和行为损害为特征的中枢神经系统退行性病变，其典型病理改变是B·淀粉样蛋白（amyloid—β，Aβ）沉积形成的老年斑和异常过度磷酸化tau蛋白形成的神经原纤维缠结。然而至今，AD的发病机制尚未完全清楚。
作者 王淑 周春奎 贾建平 秦伟
机构地区 吉林大学白求恩第一医院神经内科 首都医科大学宣武医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2012年第7期521-523,共3页 Chinese Journal of Neurology
基金 北京市教委科技计划重点资助项目（KZ200910025005）
关键词 阿尔茨海默病 脱氧核糖核酸甲基化 发病机制 磷酸化TAU蛋白 神经原纤维缠结 中枢神经系统 认知功能障碍 退行性病变
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献25

  • 1Campion D, Dumanchin C, Hannequin D, et al. Early-onset autosomal dominant Alzheimer disease : prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet, 1999,65 : 664-670. 被引量：1
  • 2Huang Y, Weisgraber KH, Mucke L, et al. Apolipoprotein E : diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer' s disease. J Mol Neurosci, 2004,23 : 189 -204. 被引量：1
  • 3Tohgi H, Utsugisawa K, Nagane Y, et al. Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex. Brain Res Mol Brain Res, 1999, 70:288-292. 被引量：1
  • 4West RL, Lee JM, Maroun LE. Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer' s disease patient. J Mol Neurosci, 1995,6 : 141-146. 被引量：1
  • 5Chen KL, Wang SS, Yang YY, et al. The epigenetic effects of amyloid-beta (1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. Biochem Biophys Res Commun, 2009, 378: 57-61. 被引量：1
  • 6Yoshikai S, Sasaki H, Doh-ura K, et al. Genomic organization of the human amyloid beta-protein precursor gene. Gene, 1990, 87 :257-263. 被引量：1
  • 7Fuso A, Nicolia V, Pasqualato A, et al. Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency. Neurobiol Aging, 2011, 32 : 187-199. 被引量：1
  • 8Lin HC, Hsieh HM, Chen YH, et al. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters. Neurotoxicology, 2009, 30:622-627. 被引量：1
  • 9Scarpa S, Cavallaro RA, D' Anselmi F, et al. Gene silencing through methylation: an epigenetic intervention on Alzheimer disease. J Alzheimers Dis, 2006, 9:407-414. 被引量：1
  • 10Nicolia V, Fuso A, Cavallaro RA, et al. B vitamin deficiency promotes tau phosphorylation through regulation of GSK313 and PP2A. J Alzheimers Dis, 2010, 19:895-907. 被引量：1

二级参考文献19

  • 1Biernat J,Mandelkow EM,Goedert M,et al.The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.EMBO J,1992,11:1593-1597. 被引量：1
  • 2Drubin DG,Kirschner MW.Tau protein function in living cells.J Cell Biochem,1986,103:2739-2746. 被引量：1
  • 3Grundke-Iqbal I,Iqbal K,Quinlan NM,et al.Microtubuleassociated protein tau:a component of Alzheimer paired helical filaments.J Biol Chem,1986,261:6084-6089. 被引量：1
  • 4Hassing L,Wahlin A,Winblad B,et al.Further evidence for the effects of vitamin B12 and folate status on episodic memory functioning:a population-based study of very old adults.Biological Psychiatry,1999,45:1472-1480. 被引量：1
  • 5Robins Wahlin TB,Wahlin A,Winblad B,et al.The influence of serum vitamin B12 and folate status on cognitive functioning in very old age.Biol Psychol,2001,56:247-265. 被引量：1
  • 6Riggs K,Spiro A,Tucker K,et al.Relations of vitamin B12,vitamin B6,folate,homocysteine to cognitive performance in the Normative Aging Study.Am J Clin Nutr,1996,63:306-314. 被引量：1
  • 7Wang HX,Wahlin A,Basun H,et al.Vitamin B12 and folate in relation to the development of Alzheimer's disease.Neurology,2001,56:1188-1194. 被引量：1
  • 8Calvaresi E,Bryan J.B vitamins,cognition,and aging:a review.J Gerontol B Psychol Sci,2001,56:327-339. 被引量：1
  • 9Gong CX,Liu F,Iqbal K,et al.Post-translational modifications of tau protein in Alzheimer's disease.J Neural Transm,2005,112:813-838. 被引量：1
  • 10Clarke R,Smith AD,Jobst KA,et al.Folate,vitamin B12,and serum total homocysteine levels in confirmed Alzheimer disease.Arch Neurol,1998,55:1449-1455. 被引量：1

共引文献1

同被引文献41

  • 1汪婷,沈军.生活方式对老年痴呆患者认知功能的影响[J].中国老年学杂志,2014,34(11):3196-3198. 被引量：14
  • 2张杰文,卢芬,李旭,索爱琴,李玮,朱良付,向莉,黄月.叶酸和维生素B_(12)对老年大鼠海马中tau蛋白磷酸化的影响[J].中华神经科杂志,2007,40(1):39-42. 被引量：2
  • 3Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer' s disease [ J ]. N Engl J Med, 2002, 346: 476-483. 被引量：1
  • 4Morrison LD, Smith DD, Kish SJ. Brain S-adenosylmethionine revels are severely decreased in Alzheimer' s disease [ J ]. Neurochem, 1996, 67 : 1328-1331. 被引量：1
  • 5Copped F, Tannorella P, Pezzini I, et al. Folate, homocysteine, vitamin BI2, and polymorphisms of genes participating in one- carbon metabolism in late-onset Alzheimer' s disease patients and healthy controls[ J]. Antioxid Redox Signal, 2012, 17: 195-204. 被引量：1
  • 6Ravaglia G, Forti P, Maioli F, et al. Homocysteine and folate as risk factors for dementia and Alzheimer disease [ J ]. Am J Clin Nutr, 2005, 82 : 636-643. 被引量：1
  • 7Wang SC, Oelze B, Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer' s disease [ J ]. PloS One, 2008, 3: e2698. 被引量：1
  • 8Chouliaras L, Mastroeni D, Delvaux E, et al. Consistent decrease in global DNA methylation and hydroxymethylation in the hippoeampus of Alzheimer' s disease patients [ J ]. Neurobiol Aging, 2013, 34 : 2091-2099. 被引量：1
  • 9Chen KL, Wang SS, Yang YY, et al. The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells [ J ]. Bioehem Biophys Res Commun, 2009, 378 : 57-61. 被引量：1
  • 10Taher N, McKenzie C, Garrett R, et al. Amyloid-[3 alters the DNA methylation status of cell-fate genes in an Alzheimer' s disease model[J]. J Alzheimers Dis, 2014, 38: 831-844. 被引量：1

引证文献2

二级引证文献13

中华神经科杂志
2012年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部