摘要
目的分析补肾清透方对慢性HBV携带者血清免疫因子的作用。方法选择符合慢性HBV携带诊断标准的患者400例,随机分为治疗组和对照组,每组200例。治疗组给予补肾清透方治疗,对照组给予安慰剂治疗,疗程52周。分别观察治疗前及治疗后血清HBV DNA定量和Th1/Th2型细胞因子[白细胞介素(interleukin,IL)-2、IL-4、IL-10和干扰素(interferon,IFN)γ]水平的变化。结果治疗52周后,治疗组血清HBV DNA下降>1 log10、>2 log10、>3 log10的患者比例明显高于对照组(P<0.01);2组HBV DNA阴转比率比较差异无统计学意义(P>0.05)。治疗组Th1细胞因子IL-2和IFNγ水平明显升高(P<0.01),Th2细胞因子IL-4和IL-10水平明显下降(P<0.01),治疗前后差值与对照组比较差异有统计学意义(P<0.01)。结论补肾清透方对抑制慢性HBV携带者HBV的复制有一定作用,可能通过恢复特异性T细胞免疫功能而实现。
Objective To investigate the effect of Bushen Qingtou prescription on serum cytokines in chronic HBV carriers. Methods Totally 400 chronic HBV carriers diagnosed according to the diagnostic standard of chronic hepatitis B carriers were randomly divided into 2 groups, a treatment group and a control group, with 200 patients in each group. The treatment group received Bushen Qingtou prescription, and the control group was given placebo. The duration of treatment was 52 weeks. The serum HBV DNA level and the levels of helper T cell （Th）l/Th2 cytokines including interleukin （IL）-2, IL-4, IL-10 and interferon （IFN） ~/in both the groups were detected before and after treatment. Results After 52 weeks of treatment, the proportions of the patients in the treatment group in whom serum HBV DNA levels decreased by more than 1 log10, 2 logl0 and 3 log10 were significantly higher than those in the control group （P〈0.01）. HBV DNA negative rates were not significantly different between the two groups （P〉0.05）. The levels of IL-2 and IFN γ increased significantly and those of IL-4 and IL-10 decreased significantly in the treatment group （P〈0.01）. Compared to the control group, the variation of the cytokine levels pre-and post-treatment in the treatment group was significantly different （P〈0.01）. Conclusion Bushen Qingtou prescription is effective in inhibiting HBV replication probably by restoring immune function of specific T cells in chronic HBV carriers.
出处
《传染病信息》
2012年第3期158-160,共3页
Infectious Disease Information
基金
国家"十一五"科技重大专项(2008ZX10005-008)
关键词
乙型肝炎病毒
免疫因子
中医药疗法
hepatitis B virus
immunologic factors
traditional Chinese medicine therapy
