摘要
目的：选取3种常见细菌性肺炎的临床类型，监测其C-反应蛋白（CRP）恢复正常的时间以及肺炎治愈_的时间，评判CRP恢复正常的时间能否作为停用抗生素的指标。方法回顾性统计分析146例细菌性肺炎病例，其中社区获得性肺炎组86例，重症肺炎组38例，呼吸机相关性肺炎组22例，分别记录各组CRP恢复正常的时间以及治愈的时间，并对结果进行统计分析。结果社区获得性肺炎组的CRP恢复正常时间与治愈时间分别为（8．00±1．12）d、（11．66±1．79）d；重症肺炎组的CRP恢复正常时间与治愈时间分别为（9．82±1．69）d、（16．08±2．52）d；呼吸机相关性肺炎组的CRP恢复正常时间与治愈时间分别为（10．73±1．45）d、（16．95±3．68）d；三组中每组的CRP恢复正常时间与治愈时间相比差异均有统计学意义（P值均〈0．01）。结论在细菌性肺炎的治疗中，CRP恢复正常的时间先于治愈时间，CRP恢复正常不能作为停用抗生素的指标。
Corresponding author ： ZOU Xiao-ying , Email ： xiaoyingzou1222~ yahoo, com. cn [Abstract] Objective To monitor the recovery time of C-reactive protein and curative time in bacterial pneumonia, judge whether the recovery time of C-reactive protein is a marker of not using antibiotic in bacterial pneumonia. Methods 146 cases of bacterial pneumonia were retrospectively analyzed,there were 86 cases of community-acquired pneumonia, 38 cases of severe pneumonia, and 22 cases of ventilator-associated pneumonia. The recovery time of C-reactive protein and curative time were recorded and analyzed respectively. Results The recovery time of C-reactive protein and curative time were respectively （8.00±1.12） days and （11.66±1.79） days in community-acquired pneumonia group, the recovery time of C-reactive protein and curative time were respectively （9.82 ± 1.69） days and （16.08±2.52） days in severe pneumonia group, the recovery time of C-reactive protein and curative time were respectively （10.73± 1.45） days and （16.95±3.68） days in ventilator-associated pneumonia group, and there were statistical significance between recovery time of C-reactive protein and curative time in every group （all P 〈0.0l）. Conclusions In the treatment of bacterial pneumonia, the recovery time of C-reactive protein is preceded to curative time, C-reactive protein is not a marker as to stop using antibiotics.
出处
《国际呼吸杂志》
2012年第12期881-883,共3页
International Journal of Respiration
基金
广西壮族自治区教育厅基金课题（201106LX082）
广西壮族自治区卫生厅基金课题（Z2010333）
