摘要
目的 探索早期应用1 3 1 I标记抗CEA单抗预防结肠腺癌肝转移的可行性。方法 在建立人结肠腺癌裸鼠肝转移后 ,于 15min、10、2 0d经尾静脉注射1 3 1 I标记抗CEA单抗 ;于放射免疫疗法后 4周和裸鼠死亡时 ,检查肝转移癌的数目、大小、瘤重、组织学和生存期。结果 早期治疗组的肝转移癌数目、大小和瘤重均明显减小 ,瘤结节内有明显坏死 ,生存期延长。结论 早期应用1 3 1
Objective To study whether liver metastasis of colonic adenocarcinoma can be prevented with early administration of 131 I labelled anti CEA monoclonal antibodies (McAbs). Methods Nude mouse model of liver metastasis of colonic adenocarcinoma was established. 131 I labelled anti CEA McAbs were injected into nude mice 15 minutes, 10 days and 20 days after the animals were inflicted with liver metastasis of adenocarcinoma. 4 weeks later and when the the animals died, the number, size and weight of the hepatic metastatic lesions and the survival time of the animals were recorded and histopathological study of the metastatic foci was done.Results In the group with early administration of 131 I labelled anti CEA McAbs, the number, size and weight of the metastatic lesions in the liver were significantly decreased, obvious necrosis was found in the lesions and the survival time of the animals was prolonged.Conclusion 131 I labelled anti CEA McAbs can efficienctly inhibit formation of liver metastasis of human colonic adenocarcinoma.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2000年第5期430-432,共3页
Journal of Third Military Medical University
基金
全军留学回国人员基金资助项目
