摘要
目的通过观察子痫前期患者血清中IFN-γ、IL-4水平,来探讨Th1、Th2型细胞因子在子痫前期疾病发病中所起的作用。方法用ELISA法分别测定正常孕妇15例、重度子痫前期患者15例、轻度子痫前期患者15例血清中IFN-γ、IL-4水平及计算IFN-γ/IL-4的比值。结果①血清中IFN-γ:轻度子痫前期组与正常妊娠组差异无统计学意义(P>0.05);重度子痫前期组明显高于正常妊娠组、轻度子痫前期组,差异有统计学意义(P<0.05)。②血清中IL-4:轻度子痫前期组与正常妊娠组相比差异无统计学意义(P>0.05);重度子痫前期组与轻度子痫前期组相比差异无统计学意义(P>0.05);重度子痫前期组低于正常妊娠组,差异有统计学意义(P<0.05)。③血清中IFN-γ/IL-4:轻度子痫前期组与正常妊娠组相比差异无统计学意义(P>0.05);重度子痫前期组与轻度子痫前期组相比差异无统计学意义(P>0.05);重度子痫前期组明显高于正常妊娠组,差异有统计学意义(P<0.05)。结论 IFN-γ和IL-4的表达失衡和紊乱可能是子痫前期免疫学发病机制中的重要环节,Th1/Th2的失衡可能是妊娠期高血压疾病发生机制之一。
Objective：To compare the expression levels of IFN-γ,IL-4 and IFN-γ/IL-4 in pre-eclamptic serum and to investigate their role in pre-eclampisa.Methods： In 15 normal pregnant women,15 mild pre-eclampsia patients and 15 severe pre-eclampsia（SPE） patients,The expression levels of IFN-γ and IL-4 in the three groups were detected by ELISA.Results：①The expression level of IFN-γ in the SPE group higher than normal pregnant and mild pre-eclampsia,and the difference is significant（P0.05）.The was no difference between the normal pregnant and mild pre-eclampsia（P0.05）.②The expression level of IL-4 in the SPE group decreased compared with the normal group,there was significantly statistical difference（P0.05）.The was no difference between the normal pregnant and mild pre-eclampsia（P0.05）.The was no difference between the mild pre-eclampsia and the normal group（P0.05）.③The ratio of IFN-γ and IL-4 in the SPE group higher than normal pregnant,and the difference is significant（P0.05）.Conclusions：The disbalant and disorder expression levels of IFN-γ and IL-4 may be one of the major links in the pathogenesis of immunology of severe pre-eclampsia.Imbalance of Th1/Th2 might lead to hypertensive disorder complicating pregnancy.
出处
《中国优生与遗传杂志》
2012年第6期48-50,共3页
Chinese Journal of Birth Health & Heredity
