摘要
目的:探讨血清IL-6、肿瘤坏死因子α(TNFα)在妊娠期高血压疾病发病中的作用。方法:应用放射免疫法分别测定26例重度子痫前期患者、27例轻度子痫前期患者及30例正常妊娠妇女血清中IL-6、TNF-α的含量。结果:子痫前期患者血清IL-6((220.08±31.82)ng·L-1)、TNFα((1.79±0.25)μg·L-1)水平均高于正常妊娠组((114.63±14.63)ng·L-1、(1.16±0.13)μg·L-1)(P<0.05)。重度子痫前期患者血清IL6((246.27±22.76)ng·L-1)、TNFα((1.99±0.17)μg·L-1)水平均高于轻度子痫前期者((199.13±20.79)ng·L-1、(1.60±0.14)μg·L-1)(P<0.05);轻度子痫前期患者血清中IL-6、TNF-α的表达高于正常妊娠组(P<0.05);血清中IL6、TNFα的表达与子痫前期的病情程度密切相关。结论:IL-6、TNF-α在妊娠期高血压疾病的发生、发展中起重要作用。
Aim: To study the role of serum interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α) in hypertensive disorder complicating pregnancy patients. Methods: Serum IL-6 and TNF-α levels were measured by using radioimmunoassay in 26 severe pre-eclampsia patients, 27 mild pre-eclampsia patients,and 30 normal pregnant women. Results:The levels of serum IL-6 and TNF-α were (220.08±31.82) ng·L -1 and (1.79±0.25) μg·L -1 in group of pre-eclampsia,which were higher than those ((114.63±14.63) ng·L -1 and (1.16±0.13) μg·L -1 ) in group of normal pregnants (P<0.05). The levels of IL-6 and TNF-α were (246.27±22.76) ng·L -1 and (1.99±0.17) μg·L -1 in group of severe pre-eclampsia,(199.13±20.79) ng·L -1 and (1.60±0.14) μg·L -1 in group of mild pre-eclampsia,which were significantly higher than those in the group of normal pregnants,and lower than those in group of severe pre-eclampsia(P<0.05).The expression of serum IL-6 and TNF-α in patients with pre-eclampsia had a close relationship with the state of the illness. Conclusion: The higher level of IL-6 and TNF-α plays an important role in the pathogenesis and development of hypertensive disorder complicating pregnancy.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2005年第3期469-470,共2页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省自然科学基金资助项目0211042900
关键词
白介素-6
肿瘤坏死因子-Α
妊娠期高血压疾病
interleukin-6
tumor necrosis factor-α
hypertensive disorder complicating pregnancy
