摘要
目的:探讨高尿酸血症与心血管疾病的相关性。方法:将41例经冠状动脉造影确诊的冠心病患者、43例非冠心病患者分别定义为观察组、对照组,根据临床症状又将观察组患者划分为稳定型心绞痛组(n=14)和急性冠脉综合征组(n=27)。测定所有患者的血清尿酸,同时测定他们的体质量指数(BMI)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(IRI)等指标。结果:观察组患者的血清尿酸显著高于对照组,二者比较差异有非常显著的统计学意义(P<0.01)。急性冠脉综合征组患者的血清尿酸显著高于稳定型心绞痛组,二者比较差异有非常显著的统计学意义(P<0.01)。观察组患者的BMI、HbA1c、IRI显著高于对照组,二者比较差异有统计学意义(P<0.05)。结论:高尿酸血症与心血管疾病的关系密切。尿酸可以作为心血管疾病发生发展的独立危险因素,是反映心血管疾病严重程度的重要指标。
Objective：To investigate the correction between hyperuricemia and cardiovascular disease.Methods：41 patients with coronary heart disease diagnosed by coronary angiography were defined as the observation group,and 43 patients with non-coronary heart disease were defined as the control group.According to the clinical symptom,the observation group were divided into 2 groups： stable angina group（n=14） and acute coronary syndrome group（n=27）.The uric acid,body mass index（BMI）,glycated hemoglobin（HbA1c）,and insulin resistance index（IRI） of all patients were determined.Results：The uric acid of the observation group was significantly higher than that of the control group（P〈0.01）,and the uric acid of the acute coronary syndrome group was significantly higher than that of the stable angina group（P〈0.01）.The BMI,HbA1c,IRI of the observation group were significantly higher than those of the control group,respectively（P〈0.05）.Conclusion：Hyperuricemia and cardiovascular disease are related closely.The uric acid is considered as independent risk factor for cardiovascular disease,and it can reflect the severity of cardiovascular disease too.
出处
《中国医药导刊》
2012年第6期987-988,共2页
Chinese Journal of Medicinal Guide
