摘要
报道了 3 -芳氧甲基 /芳基 -4 -氨基 -5 -巯基 -1 ,2 ,4-三唑和芳酸在三氯氧磷作用下合成了 1 6个标题化合物。其结构经元素分析、IR,1H NMR和 MS确证。同时研究了反应条件。抗菌试验表明部分化合物具有较强的生物活性。
Sixteen title compounds had been prepared by the reaction of 3-aryl/aryloxymethene-4-amino-5-mercapto-1,2,4-triazoles with aryl carboxylic acids in the presence of phosphorus oxychloride and their structures had been confirmed by elemental analysis, IR, 1H NMR and MS. These compounds were screened for their biological activities. Bacteriostatic tests indicated that some of them possess strong biological activities. The synthetic reaction conditions had also been investigated.
出处
《合成化学》
CAS
CSCD
2000年第3期226-230,255,共6页
Chinese Journal of Synthetic Chemistry
基金
安徽省自然科学基金
安徽省教委基金
关键词
三唑并噻二唑
稠环化合物
合成
生物活性
结构
Triazole
Thiadiazole
Arylcarboxylic acid
Phosphorus oxychloride
Biological activity
Synthesis.
