摘要
背景:自体骨髓间充质干细胞移植是近年来在治疗关节软骨缺损较新的方法,但在临床上,急性骨软骨缺损很难在短时间内应用自体骨髓间充质干细胞修复,而同种异体的骨髓间充质干细胞可以提前制备,以备应用。目的:系统分析同种异体骨髓间充质干细胞的免疫调节及抑制研究。方法:以"Bone Mesenchymal Stem Cells,immunomodulation activity,immunosuppression;同种异体骨髓基质干细胞,免疫调节活性,免疫抑制"为关键词,由第一作者检索1990/2009PubMed及万方数据库有关同种异体骨髓间充质干细胞免疫调节及抑制研究方面的文献。结果与结论:虽然移植同种异体细胞有可能被受体体内的免疫系统攻击,但骨髓间充质干细胞是例外,因为它是免疫调节细胞,具有抑制免疫反应的作用。骨髓间充质干细胞对T细胞、B细胞、自然杀伤细胞和抗原提呈细胞均具有抑制作用。骨髓间充质干细胞是从骨髓中分离出来的组织工程细胞群,它携有免疫抑制相关标志,并在体外抑制同种异体T细胞增殖,因此骨髓间充质干细胞可用于同种异体细胞治疗。骨髓间充质干细胞为临床上同种异体骨髓间充质干细胞修复于关节软骨缺损提供了一种崭新的方法。
BACKGROUND： Autologous bone marrow mesenchymal stem cells transplantation is a new method in recent years for the treatment of articular cartilage defects. However, in the clinic, the autologous bone marrow mesenchymal stem cells cannot be used to repair the acute osteoehondral defect in a short time, and allogeneic bone marrow mesenchymal stem cells can be in advance prepared for the application. OBJECTIVE： To symmetrically analyze the immunomodulation activity and inhibition studies of allogeneic bone marrow mesenchymal stem cells. METHODS： The PubMed database and Wanfang database from 1990 to 2009 were used to search the articles describing to the immunomodulation activity and inhibition studies of allogeneic bone marrow mesenchymal stem cells by the first author with the key words of ＂bone mesenchymal stem cells, immunomodulation activity, immunosuppression＂ in English and Chinese. RESULTS AND CONCLUSION： Although the transplantation of allogeneic cells may be attacked by the immune system, bone marrow mesenchymal stem cell is an exception, as it is the regulatory T cell that can suppress the immune response. Bone marrow mesenchymal stem cells can inhibit the T cells, B cells, natural killer cells and antigen presenting cells. Bone marrow mesenchymal stem cells are the tissue engineering cell group that isolated from the bone marrow; it has the immunosuppression related marks, and can inhibit the proliferation of allogeneic T cells in vitro, so the bone marrow mesenchymal stem cells can be used for ailogeneic cell therapy. Bone marrow mesenchymal stem cells provide a new method for the repair of articular cartilage defects in the clinic by allogeneic bone marrow mesenchymal stem cells.
出处
《中国组织工程研究》
CAS
CSCD
2012年第23期4306-4309,共4页
Chinese Journal of Tissue Engineering Research
