摘要
采用反相高效液相色谱-紫外检测法对盐酸西替利嗪血药浓度测定方法及药物动力学进行了研究。应用C18柱,于血浆沉淀蛋白后直接进样分析,平均回收率90.1%。线性范围40.0～1200ng/ml,最低检测限1.2ng。8名健康受试者口服盐酸西替利嗪片的药动学参数分别为:Cmax709.8±48.5ng/ml,Tmax1.1±0.6h,t1/29.3±1.9h,MRT8.7±1.0h,AUC0→T(n)4879.6±1553.4ng·h·ml-1。
A rapid and sensitive RP HPLC method with average recovery 90.1% and the lowest detective concentration of 40ng/ml was developed for determining cetirizine hydrochloride in human plasma,using C 18 column,detective wavelength 230nm and plasma sample deproteinized by methanol. After oral administrations of a single dose of 20mg cetirizine hydrochloride tablets to each of 8 healthy volunteers in a randomized cross over design,the pharmacokinetic parameters were obtained.The values of C max , T max , t 1/2 , MRT and AUC 0→T(n) were 709.8 ±48.5ng/ml, 1.1±0.6h, 9.3±1.9h, 8.7±1.0h, 4879.6±1553.4ng·h·ml -1 , respectively.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2000年第3期124-127,共4页
Chinese Journal of Pharmaceuticals
关键词
盐酸西替利唪
血药浓度
高效液相色谱法
cetirizine hydrochloride
tablets
plasma drug concentration
pharmacokinetics
HPLC determination
