摘要
目的 :对血浆钠 <130mmol·L-1,利尿剂作用减弱 ,腹水消失时间延长的 5 6例肝硬化腹水病人 ,静脉补充 3%氯化钠(NaCl) ,观察利尿剂作用的效果。方法 :根据血浆钠检测结果及尿量变化 ,日补充 3%NaCl 30 0ml,连续使用 1～ 7d ,平均每人输注 45 5 .8ml。结果 :输注 3%NaCl后 6h尿量开始增加 ,2 4h增加 5 0 0～ 15 0 0ml,利尿剂作用明显增强 ,腹水消失时间缩短 ,与对照组相比差异具有显著性 (P <0 .0 1)。结论 :血浆钠 <130mmol·L-1时利尿剂作用明显减弱 ,血浆钠越低 ,利尿剂作用越弱。
OBJECTIVE:56 patients with cirrhotic liver and ascites were replenished 3% NaCl by intravenous drop.All of them had three features:the concentration of plasma Na<130 mmol·L -1 ,the action of diuretics weakened and the time of ascites vanishing prolonged,then the enhancing effects of diuretic's action was observed.METHODS:According to the effects of plasma Na concentration and the difference of urine quantity,each patient was replenished 3% NaCl 300 ml every day for 1～7 days by intravenous drop,the average in per person was 455.8 ml.RESULTS:With these patients were replenished 3% NaCl by intravenous drop,the urine quantity began to increase ofter 6 h and the total of increased quantity could reach between 500 ml and 1 500 ml within 24 h.The action of diuretics enhanced obviously and the time of ascites vanishing was shortened.Compares with control group,the difference was remarkable( P < 0.01 ).CONCLUSIONS:When the concentration of plasma Na<130 mmol·L -1 ,the action of diuretics reduces obviously.The lower the concentration of plasma Na,the weaker the action of diuretics.We should pay attention to replenish NaCl when diuretics are used.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2000年第4期224-225,共2页
Chinese Journal of Hospital Pharmacy
关键词
肝硬化
腹水
利尿剂
高渗氯化钠
cirrhotic liver
ascites
diuretic
high concentration of chloride
