摘要
目的:探讨气管内滴注利多卡因对急性肺损伤(ALI)治疗作用。方法:选择合并有ALI的气管切开患者40例,随机分为治疗组20例与对照组20例。治疗组采用0.5%利多卡因在吸痰前气管滴入2～3ml,并每间隔1h再次滴入;或采用生理盐水500ml+5%碳酸氢钠80ml+2%利多卡因20ml持续气管内滴入,3～5滴/min。对照组采用生理盐水在吸痰前气管滴入2～3ml,并每间隔1h再次滴入;或采用生理盐水500ml+5%碳酸氢钠80ml持续气管内滴入,3～5滴/min。观察记录两组血氧饱和度(SaO2)及动脉血气分析观察氧合指数(PaO2/FiO2)。结果:两组SaO2、PaO2/FiO2在治疗前差异无统计学意义(P>0.05);治疗组6hSaO2较对照组明显升高(P<0.05),PaO2/FiO2亦较对照组明显升高(P<0.01)。结论:利多卡因气管内滴入对多种原因所致的急性肺损伤疗效确切,可改善氧合,终止其发展为ARDS。
Objective： To discuss the effect of endotracheal lidocaine drips on the patients with acute lung injury. Methods： 40 patient with ALI were randomly divided into treatment group（20 cases）and control group（20 cases）. The treatment group was treated with 2-3 ml 0.5% lidocaine by intratracheal instillation before sputum aspiration and each one hour interval, or with 3-5 drips of the solution per minute which composed of 500 ml physiological saline, 80 ml 5% sodium bicarbonate and 20 ml 2% lidocaine continuously by intratracheal instillation. The control group was given 2-3 ml physiological saline by intratracheal instillation before sputum aspiration and each one hour interval, or with 3-5 drips of the solution per minute which composed of 500 ml physiological saline, 80 ml 5% sodium bicarbonate continuously by intratracheal instillation. Degree of blood oxygen saturation and oxygenation index（PaO2/FiO2） were observed in the two groups. Results： There was no statistically significant（P〉0.05） between the two groups on the degree of SaO2 and PaO2/FiO2 before the treatment. But the degree of SaO2 at 6 hours after the treatment in the treatment group was significantly higher than that in the control group（P〈0.05）, especially the PaO2/FiO2（P〈O.O1）. Conclusion： Intratracheal instillation with lidocaine has exact efficacy on acute lung injury caused by a variety of reasons. It can improve the oxygenation of the patient with ALI and stop the development from ALI to ARDS.
出处
《中国医学创新》
CAS
2012年第18期3-5,共3页
Medical Innovation of China
