摘要
目的通过测定特发性血小板减少性紫癜（ITP）患儿血清中干扰素-γ（IFN-γ）、白细胞介素-6（IL-6）及肿瘤坏死因子-α（TNF—α）的含量，从细胞因子水平探索ITP的发病机制。方法选择ITP患儿急性发作期组35例，缓解期组30例，另选择20名健康儿童作为对照组，采用ELISA法检测血清IFN-α、IL-6和TNF—α水平分析比较。结果ITP患儿血清IFN-γ、IL-6和TNF-α水平急性发作期组明显高于缓解期组和对照组，且缓解期组亦高于对照组，差异均有统计学意义（P均〈0．05）。结论IFN-γ、IL-6和TNF-α均参与了ITP的发病机制，通过测定细胞因子IFN-γ、IL-6和TNF-α水平可以判断ITP的病情。
Objective To study the pathogenesis of idiopathic thrombocytopenic purpura（ITP） in cytokine levels by detecting the serum levels of IFN-γ, IL-6 and TNF-α in children with ITP. Methods Acute exacerbation group （rt = 35 ）and remission group （n = 30）with ITR were choosed, and 20 healthy children were choosed as normal controls. Serum IFN-γ,IL-6 and TNF-α levels were measured by EIASA, and the results were compared and analyzed. Results The serum levels of IFN-γ, IL-6 and TNF-α in children with acute exacerbation group were markedly higher than those in remission group and healthy controls, and the serum levels of IFN-γ,IL-6 and TNF-α in remission group were markedly higher than those in healthy controls （P 〈 0.05 ）. Conclusions IFN-γ, IL-6 and TNF-α may take part in the etiology of ITP.
出处
《中国实用医刊》
2012年第14期10-11,共2页
Chinese Journal of Practical Medicine
