摘要
目的：探讨正常志愿者膝关节软骨的T2及T2＊弛豫值范围、影响因素及其内在相关程度。方法：将63名健康人胫股关节按照年龄分为青少年组（〈35岁）18人、中年组（36~55岁）28人和老年组（56~78岁）17人,计算体重指数（BMI）并行T2图、T2＊图成像,按照全器官磁共振成像评分（WORMS）规定的软骨分区法测量胫股关节软骨10个感兴趣区的T2、T2＊弛豫率并取平均值,然后进行统计学分析。结果：健康人胫股关节软骨T2、T2＊值分别为（42.98±4.19）ms、（19.75±2.43）ms。左右膝胫股关节T2、T2＊值分别为（43.60±4.08 ms,42.37±4.26 ms）、（19.29±2.48 ms,20.21±2.37 ms）,经检验两者均无明显统计学差异（P〉0.05）。女性及男性胫股关节软骨T2、T2＊值分别为（44.28±5.14 ms,41.86±4.09 ms）、（19.36±2.48 ms、20.09±2.42 ms）,亦无明显统计学差异（P〉0.05）。青少年组、中年组及老年组胫股关节软骨的T2、T2＊值分别为（37.45±1.76 ms,41.29±2.13 ms,44.98±4.73 ms）、（17.95±1.58 ms,20.76±1.52 ms,22.30±2.08 ms）,三组间有明显统计学差异（P〈0.01）。青少年组、中年组及老年组三组内T2、T2＊值均呈显著相关（P〈0.05,Pearson相关系数分别为0.61、0.63、0.55）。结论：正常人胫股关节软骨T2及T2＊弛豫值研究可以为关节软骨早期病变的诊断提供相似的参考价值,定量测定T2＊值有望替代传统的T2值用于研究软骨形态学改变之前软骨内生化成分的变化。
Purpose： To probe the characteristics of T2 and T2＊ relaxation time of tibiofemoral articular cartilage in asymptomatic volunteers. Methods： T2 and T2＊ mapping were performed on 63 healthy tibiofemoral articular cartilages, which were stratified by age for 3 cohorts： young-aged （17-35y, n=18）, middle-aged （36-55y, n=28） and old-aged （56-78y, n=17）. T2 and T2＊ values of tibiofemoral articular cartilage in 10 sub-regions based on the Whole-Organ Magnetic Resonance Imaging Score（WORMS） and body mass index（BMI） were calculated. Results： The global T2 and T2＊ values were （42.98＋4.19）ms and （19.75＋2.43） ms respectively. The average T2 and T2＊ relaxation time of left and right knees were （43.60＋4.08 ms, 42.37＋4.26 ms） and （19.29＋2.48 ms, 20.21＋2.37 ms） respectively, and there was no significant difference between them（P〉0.05）. The average T2 and T2＊ values of women and men were （44.28＋5.14 ms, 41.86＋4.09 ms） and （19.36＋2.48 ms, 20.09＋2.42 ms） respectively, and there was no significant difference between them （p〉0.05）. The average T2 and T2＊ relaxation time of young-aged, middle-aged and old-aged were （37.45 ＋ 1.76 ms, 41.29＋2.13 ms, 44.98＋4.73 ms） and （17.95＋1.58 ms, 20.76~1.52 ms, 22.30＋2.08 ms） respectively, and there was significant difference among them （P〈0.01）. The T2 and T2＊ values in the 3 cohorts were all showed with significant correlation, Pearson correlation coefficients were 0.61, 0.63 and 0.55 respectively （from the young-aged to the old-aged）. Conclusion： With this feasibility study, both T2 and T2＊ relaxation parameters demonstrated a similar response in the assessment of healthy Tz＊ relaxation is expected to be a substitute for conventional composition before morphological changes of the cartilage. tibiofemoral articular T2 value to study the cartilages. changes in Quantitative biochemical
出处
《中国医学计算机成像杂志》
CSCD
北大核心
2012年第3期238-242,共5页
Chinese Computed Medical Imaging
基金
国家自然科学基金面上项目(81171312)
上海市科委医学引导项目(1041196600)资助~~
关键词
胫股关节软骨
磁共振成像
T2图
T2＊图
Tibiofemoral articular cartilage
MR imaging
T2 mapping
T2 star mapping
