摘要
食物过敏(food allergy,FA)是指机体针对摄入的食物蛋白产生的一种有害的免疫反应.2007年疾病预防与控制中心(CDC)数据显示,年龄在18岁以下儿童发生食物过敏者超过3百万(3.9%),5岁以下发病率更高.本文阐述了健康的肠道菌群对促使免疫系统成熟有非常重要的作用,食物过敏与非过敏婴儿间肠道菌群组成确实不同.儿童食物过敏与肠道黏膜屏障的破坏、黏膜屏障成分的发育不成熟、肠道菌群失调、肠道菌群紊乱密切相关.益生菌(probiotics)作为肠道微生态的平衡者和肠黏膜免疫系统调节者,对防治过敏性疾病的发生可能具有适度的作用,但需要更进一步的、更多的大样本随机对照临床研究.
A food allergy is defined as a harmful immunological reaction to ingested food protein. According to 2007 CDC statistics, more than 3 million (3.9%) of children under 18 years old suffered from food allergy, and the morbidity is especially higher among children under 5 years old. Healthy intestinal microflora is very important for the development of mature human immune system. The composition of intestinal microflora differs significantly between children with and without food allergy. Food allergy in children may be closely associated with the immature development and damage of the intestinal mucosal barrier, intestinal dysbacteriosis and microflora disorder. Probiotics, as the balancer of intestinal microflora and regulator of intestinal mucosal immunity, can be used to prevent and treat allergic diseases; however, more larger randomized, controlled clinical studies are needed to verify its efficacy.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第16期1421-1427,共7页
World Chinese Journal of Digestology
基金
云南省中青年学术技术带头人后备人才培养计划基金资助项目
No.2006PY1-18~~
关键词
食物过敏
肠道菌群
肠黏膜屏障
益生菌
Food allergy; Intestinal microflora; Intestinal mucous barrier; Probiotics