摘要
目的 :评价泮托拉唑治疗十二指肠溃疡的疗效。方法 :共 10 0例活动期十二指肠溃疡患者 ,随机分为泮托拉唑治疗组和兰索拉唑对照组。用药 4周后复查胃镜 ;采用积分法记录治疗前后患者的症状 ;记录治疗期间出现的不良反应。结果 :治疗组临床症状积分与对照组积分无显著差异 (P >0 .0 5 ) ;疼痛缓解时间分别为 (2 .5± 0 .8)和 (2 .4± 0 .5 )d ,P >0 .0 5 ;两组治疗 4周后胃镜检查结果分别为 :痊愈 44例 (88% )和 43例 (86 % ) ,显效率 92 %和88% ,总有效率 98%和 96 % ,两组间无显著差异 (P >0 .0 5 ) ;未出现严重不良反应。结论 :泮托拉唑 40mg治疗十二指肠溃疡 ,其疗效与兰索拉唑 30mg相似 ,具有促进溃疡愈合。
OBJECTIVE:To evaluate the therapeutic effect of pantoprazole on duodenal ulcer.METHOD: One hundred consecutive patients who were confirmed as active duodenal ulcer by endoscopy were received pantoprazole (40mg,qd) or lansoprazole (30mg,qd) as control.At 4 weeks after treatment,endoscopic changes of ulceration were re-evaluated.Symptom were noted by using a scoring system. Side effects were also observed.RESULTS: There were no significant difference in clinical symptom scores between pantoprazole and lansoprazole treatment.The mean pain relief period was ( 2.5 ±0.8) in pantoprazole and (2.4± 0.5 ) d in lansoprazole ( P >0.05).Total effective rate was 98% in pantoprazole and 96% in lansoprazole,respectively.CONCLUSION: Pantoprazole showed its high effect in the treatment of duodenal ulcer.
出处
《中国新药杂志》
CAS
CSCD
2000年第2期120-122,共3页
Chinese Journal of New Drugs
