摘要
本研究通过分析磁共振弥散张量成像(diffusion tensor imaging,DTI)数据,观察内侧颞叶癫痫(mesial temporal lobe epilepsy,mTLE)患者大脑白质的改变。46例伴有单侧海马硬化的内侧颞叶癫痫患者(24例左侧颞叶癫痫和22例右侧颞叶癫痫),以及42例年龄和性别匹配的正常志愿者纳入本研究。采用基于纤维束追踪的空间统计分析方法(track-based spatialstatistics,TBSS),主要观察患者各向异性系数(fractionsal anisotropy,FA)的变化。结果发现,与正常志愿者相比,左侧mTLE患者FA降低的区域呈双侧分布,稍偏向患侧,胼胝体、上纵束、下纵束、内囊前肢等白质双侧都有异常,而扣带束、下额枕束只在左脑显著降低;右侧mTLE患者FA降低主要见于右脑,包括胼胝体、上纵束、下纵束和钩束等。结果表明,基于TBSS方法的DTI研究揭示了伴有海马硬化的mTLE患者的脑白质异常,有助于加深对mTLE病理生理机制的了解。
Magnetic resonance diffusion tensor imaging （DTI） data were analyzed in this study, and the white matter abnormalities in patients with mesial temporal lobe epilepsy were observed using tract-based spatial statistics （TBSS）. 46 mTLE patients （24 with left hippocampal sclerosis （LHS） and 22 with right hippocampal sclerosis（RHS）） and 42 age- and gender-matched healthy volunteers were involved in the study. Voxel-wise group comparison of white matter fractional anisotropy （FA） was performed using TBSS. FA reduced with LHS patients showed a bilateral distribution, slightly to the affected side, including the corpus callosum, superior and inferior longitudinal fasciculus, anterior limb of internal capsule, etc. In addition, the interior fronto-occipital fasciculus and the cingulate bundle were only found a significant reduction in the left halves of the brain. RHS groups had significantly lower fractional anisotropy which was localized to the right brain, including the corpus callosum, superior and inferior longitudinal fasciculus, uncinate fasciculus, etc. Diffusion tensor imaging analysis with TBSS reflected white matter changes in mTLE with HS. These results contributed to understand the physiopathologic mechanism of mTLE.
出处
《生物物理学报》
CAS
CSCD
北大核心
2012年第6期477-485,共9页
Acta Biophysica Sinica
基金
国家自然科学基金项目(61075107
30971019)
全军医学科技"十二五"科研重点项目(BWS11J063)
南京军区重点医药基金资助项目(10z026)
教育部人文社科研究项目(11YJC190039)~~
关键词
磁共振弥散张量成像
内侧颞叶癫痫
海马硬化
纤维束追踪的空间统计
Diffusion tensor imaging
Mesial temporal lobe epilepsy
Hippocampal sclerosis
Tract-basedspatial statistics（TBSS）
