摘要
目的探讨肺癌肿瘤抑制物1(TSLCl)和Wnt-1诱导分泌蛋白3(WISP-3)在非小细胞肺癌(NSCLC)组织中的表达及两者与NSCLC临床特征之间的关系。方法采用免疫组织化学法检测80例NSCLC患者手术切除的癌组织和癌旁组织中TSLC1和WISP-3表达水平。结果TSLC1在NSCLC癌组织中的表达率为30.00%(24/80),明显低于在癌旁组织中表达率71.25%(57/80),两者差异有统计学意义(P〈0.01),WISP-3在NSCLC癌组织中的表达率为67.50%(54/80),明显高于在癌旁组织中表达率16.25%(13/80),两者差异有统计学意义(P〈0.01)。TSLC1表达水平与NSCLC组织学分化程度、TNM分期、淋巴结转移有关(P〈0.05),WISP-3表达水平与NSCLC组织学分化程度、TNM分期、年龄明显相关(P〈0.05)。结论TSLC1和WISP-3可能参与NSCLC的发生发展,并可能是NSCLC预后相关指标。
Objective To investigate the expression of tumor suppressor in lung cancer 1 (TSLC1) and WISP-3 in non-small cell lung carcinoma (NSCLC) , and their relation to the clinicopathological features. Methods Envision immunohistoehemieal method were used to assess the expression of TSLC1 and WISP-3 in 80 cases of human NSCLC tissues and non-cancerous adjacent lung tissues. Results The expression rate of TSLC1 in was 30.00% (24/80) in NSCLC tissues, and 71.25% (57/80) in non-cancerous adjacent lung tissues (P 〈0. 01 ) , the expression rate of WISP-3 was 67.50% (54/80) in NSCLC tissues, and 16. 25% (13/80) in non-cancerous adjacent lung tissues (P 〈 0. 01 ). the expressions of TSLC1 were related to histology grade, TNM stage and lymph node metastasis (P 〈 0. 05 ), there was a close relation between the expression of WISP-3 and histology grade, TNM stage and age ( P 〈 0. 05 ). Conclusion TSLC1 and WISP-3 may participate in the development and progression of NSCLC, and may be used to predict the prognosis of NSCLC patients.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2012年第6期1146-1147,共2页
Chinese Journal of Experimental Surgery