摘要
Wnt-1诱导分泌蛋白3(WISP-3),是CCN家族成员之一,也称CCN6。它与大多数CCN家族成员的结构和功能相似,可编码多种细胞外基质蛋白,参与细胞的增殖分化与凋亡的调控,并可促进神经、血管、骨骼的发育。WISP-3表达水平的不同与多种恶性肿瘤的发生和发展有关,已成为CCN家族的研究热点之一。
Wnt-1-induclhle Secreted Protein 3 （WISP-3） belongs to CCN family. The structure and function of WISP-3 are similar to other members of the CCN family,which encods a varied extracelluar matrix proteins taking part in cell proliferation, differentiation and apoptosis and promoting the development of nerves, blood vessel and skeleton. The different expression of WISP-3 has been demonstrated to he associated with tumors in varied tissues,whlch has become one of hot topics in the study on CCN family.
出处
《医学综述》
2008年第16期2433-2435,共3页
Medical Recapitulate
