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5羟色胺1B受体在小鼠耳蜗螺旋神经元上的表达及意义 被引量:2

Localization and significance of serotonin receptor 1B in the spiral ganglion in micee
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摘要 目的研究小鼠耳蜗螺旋神经元上5羟色胺(serotonin,5-HT)1B受体的表达并探讨其意义。方法采用成熟昆明小鼠耳蜗石蜡切片,运用免疫组化技术检测耳蜗螺旋神经元上5羟色胺1B受体的表达。结果实验组小鼠耳蜗螺旋神经元胞浆内显示阳性表达信号,阴性对照组未发现阳性信号。结论 5羟色胺1B受体存在于听觉传导通路的第一级神经元,支持5羟色胺作为其递质,对神经兴奋性起着重要的调节作用。 Objective To investigate the expression of serotonin. (5-HT) receptor 1B in spiral ganglion and its' significance. Methods In the cochlear paraffin slides, The immunohistochemistry technique was used to locate serotonin receptor 1B in the spiral ganglion. Results Apositive signal was showed in the experimental group, as a negative signal was showed in the control group without serotonin receptor 1B antibody. Conclusion The results demonstrate that the spiral ganglion neurons contain serotonin receptor lB. It strongly indicates that serotonin as a neurotransmitter plays an important role in regulating neural activity.
出处 《西部医学》 2012年第6期1056-1058,共3页 Medical Journal of West China
基金 由国家自然科学基金课题(30872844)和(30471880)共同资助
关键词 螺旋神经元 5羟色胺 受体 神经递质 免疫组化技术 Spiral ganglion neuronl Serotoninl Receptorl Neurotransmitter Immunohistochemistry technique
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