摘要
目的 评价持续气道内正压（ＣＰＡＰ）治疗阻塞性睡眠呼吸暂停综合征（ＯＳＡＳ）的疗效，建立预测ＣＰＡＰ压力值的指标。方法 ５４例ＯＳＡＳ患者，ＣＰＡＰ前后作全夜多导睡眠图监测，分析最佳治疗压力与监测参数相关性，推导回归方程；比较预测压力与实测压力符合率及疗效。结果 ＣＰＡＰ治疗后呼吸紊乱指数、暂停时间和氧饱和度均明显改善（Ｐ＜０．００１）；ＣＰＡＰ压力与氧饱和度低于９０％占睡眠时间百分比（ＴＳ ９０％）显著相关（ｒ＝０．５４８，Ｐ＜０．００１）；预测压力与实测压力疗效无显著差异（Ｐ＞０．０５）。结论ＣＰＡＰ疗效肯定；ＴＳ９０％可用于预测ＣＰＡＰ治疗压力。
Objective To evaluate efficacy and to predict an optimal level of continuous positive airways pressure (CPAP) in the treatment of obstructive sleep apnea(OSA). Methods 54 patients with OSA were studied. Their actual levels of CPAP(P) were determined by the polysomnographic (PSG) system plus CPAP system. The relationship between actual P and parameters of PSG were analyzed. The correlation regression equations were calculated. 40 patients (group A) were treated with actual P and 15 patients (group B) were treated with predicted P which was derived from the regression equation. Results The result showed respirotory disturbance index and sleep hypoxemia were improved significantly after CPAP treatment (46± 18 υs 3 ± 4, 71 ± 10 υs 90± 7, P<0.001). There was a close positive linear correlation between TS 90%(the percentage of time under SaO2<90% over total sleep time) and actual P (r=0.548, P<0.001). In efficacy there was no significant difference between group A and group B. Conclusion it was suggested that CPAP is an effective treatment for OSA, and the parameter of TS 90% is valuable and simple in predicting the pressure level of CPAP.
出处
《上海第二医科大学学报》
CSCD
2000年第2期122-124,共3页
Acta Universitatis Medicinalis Secondae Shanghai
基金
卫生部科研基金!(96- 2- 280)
