摘要
目的:评价血浆1-3-β-D葡聚糖检测诊断侵袭性肺部真菌感染临床应用价值。方法:分析2009年1月-2010年6月我院送检的99例气管镜吸引痰标本,其中真菌培养阳性者32例,真菌培养阴性者67例。99例患者同时进行血浆1-3-β-D葡聚糖检测,分析比较两组葡聚糖水平,应用ROC曲线评价1-3-β-D葡聚糖诊断肺部真菌感染的临床价值。结果:肺部真菌培养阳性组1-3-β-D葡聚糖水平明显明显高于阴性组(34.7.6±20.0 vs 10.4±6.9,t=8.9 P<0.0001);血浆1-3-β-D葡聚糖诊断肺部真菌感染的ROC曲线下面积为0.89(95%CI:0.82%～0.96%);以20 ng/L为Cutt-off值诊断肺部真菌感染的敏感度为92.4%(95%CI:83.2%～97.5%),特异度为75.0%(95%CI:56.6.2%～88.5%)。结论:痰培真菌沛养阳性患者血浆葡聚糖水平明显升高,其诊断肺部真菌感染有一定的临床参考价值。
Objective：To evaluate the clinical value of plasma 1-3-β-D glucan in diagnosis of invasive pulmonary fungal infection.Methods： 99 sputum specimens were collected for fungal cultivation from January 2009 to June 2010 in our hospital.32 specimens were fungal cultivation positive and 67 were negative.The plasm 1-3-β-D glucan of the patients were tested for comparison between the two groups.The ROC curve was used to evaluate the diagnosis effect of plasm 1-3-β-D glucan.Results： The plasm 1-3-β-D glucan level was much higher in fungal cultivation positive group compared with fungal cultivation negative group（34.7.6±20.0 vs 10.4±6.9,t=8.9 P〈0.0001）.The under-curve-area（AUC） of plasm 1-3-β-D glucan for diagnosis of pulmonary fungal infection was 0.89（95%CI：0.82%~0.96%）.The sensitivity and specificity was 92.4%（95%CI：83.2%~97.5%）and 75.0%（95%CI：56.6.2%~88.5%）at the cutt-off level of 20 ng/L.Conclusion： The plasm 1-3-β-D glucan was elevated in the fungal cultivation positive group.It can provide some diagnosis information for testing plasm 1-3-β-D glucan.
出处
《中国卫生检验杂志》
北大核心
2012年第5期1039-1041,共3页
Chinese Journal of Health Laboratory Technology
