摘要
目的探讨非小细胞肺癌脑转移不同治疗方案的疗效。方法分析60例肺癌脑转移患者的临床特点。结果单因素分析结果提示原发病治疗方法、脑部放疗方式、T分期、颅外转移数目对患者生存期有影响(P<0.05)。全脑放疗联合全身化疗优于单纯放化疗。Cox模型多因素分析显示脑转移瘤不同治疗方案为独立预后因素(P=0.0001)。结论脑转移瘤不同治疗方案是影响预后的独立预后因素,积极的多学科综合治疗疗效优于单纯全脑放疗。
Objective To evaluate the prognostic factors of lung cancer patients with brain metastases and to study the effect of treatment modality of brain metastases.Methods A retrospective review was performed evaluating 60 patients diagnosed as lung cancer with brainmetastasis.Statistical analysis was performed using the Kaplan-Meier method and Cox-regression analysis.Results Univariate analysis showed that the following variables had effect on survival： the therapy to control primary tumor,treatment modality of brain metastases,T stag of the tumor,number of extra cranial metastases（P0.05）.Univariate analysis showed a better survival for the combination of whole brain radiotherapy and chemotherapy（P=0.0001）.Based on Cox-regression analysis,treatment modality of brain metastases was the only independent predictor of survival.Conclusions Treatment modality of brain metastases is the only independent predictor of survival.Aggressive combined therapy of brain metastases may achieve a survival advantage.It is proposed to provide combined therapy of whole brain radiotherapy and other diverse therapy in patients of good quality status.
出处
《临床肺科杂志》
2012年第7期1273-1275,共3页
Journal of Clinical Pulmonary Medicine
关键词
肺肿瘤
脑肿瘤
肿瘤转移
预后
Lung neoplasms
Brain neoplasms
Neoplasm metastasis
Prognosis
