摘要
文献报告小鼠HAC瘤株皮下移植后的血浆粘度和全血粘度比对照组明显增高。本组曾利用血道转移模型和血道合并淋巴道转移模型探讨癌细胞侵袭和转移过程中几种血液流变学指标的变化规律,发现在侵袭期呈明显升高的趋势,而到转移期,尤其是到转移晚期,又明显下降。
Mouse transplantable hepatoma (H22) was used as an experimental model for lymphatic metastasis . The tumor cells were transplanted subcutaneously into right footpads of inbred 615-strain mice. The hemorheological changes during invasion and lymphatic metastasis in mice were observed . The results of histological examination showed that tumor invasion was divided into early , middle and late invasive stages , and the metastasis was divided into early , middle , late and final metastasis periods . Tumor invasion began 3 days after tumor transplantation , and the late stage of invasion was found at 9 days. Metastasis began 6 days after transplantation ; at 19 days metastasis to lymph nodes in the right side reached grade IV . Metastasis to lymph nodes in the left side appeared 14 days after tumor transplantation . In the early and middle invasive stages only plasma viscosity increased significantly , while other hemorheological values were unchanged. The blood viscosity and aggregation of red blood cells decreased significantly after the metastatic late stage. The hematocrit of red blood cells began to decrease in the final stage of metastasis, and in the meantime, the rigidity of red blood cells began to increase, while plasma viscosity showed no changes after the late metastatic stage. The results and mechanism of hemorheological changes are discussed .
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1990年第4期300-305,共6页
Acta Academiae Medicinae Sinicae
