摘要
[目的]探讨生产性含镍粉尘的致癌作用。[方法]Wistar雄性大鼠随机分为3组:选矿组和冶炼组分别暴露于镍选矿及冶炼车间,自然吸入粉尘,正常对照组饲养于职工医院生活区。实验全程历时2年,结束后对大鼠做详细的病理组织学检查。[结果]现场暴露共诱发肺部肿瘤4例,选矿组1例为肺腺癌(检出率为14.3%),冶炼组3例(其中2例肺腺癌,1例肺鳞癌),检出率为42.9%。肺部肿瘤平均潜伏期为20.5个月。[结论]吸入镍冶炼车间粉尘有一定程度致癌作用,选矿车间粉尘致癌作用较弱。
[ Objective ] To study the carcinogenicity of industrial nickel dust in rats by inhalation study. [ Methods ] Male Wistar rats were divided into 3 groups： 2 test groups were exposed to mineral dust at scintillation site and dust at smelt site respectively for 2 years; and 1 control group was raised at non-exposure area with normal feeding. Histopathological examinations were then carried out on the rats survived or died during the experiment. [ Results ] A total of 4 cases of pulmonary tumors were induced in 2 test groups： 1 pulmonary adenocarcinoma case in mineral dust group （positive rate was 14.3%）; 2 pulmonary adenocarcinoma cases and 1 pulmonary squamous cell carcinoma case in smelt dust group （positive rate was 42.9%）. The average latency period for lung cancer was 20.5 months. [ Conclusion ] Industrial nickel dust in smelting workshops may be carcinogenic to rat, and that in ore scintillation workshops may possess weaker carcinogenic activity.
出处
《环境与职业医学》
CAS
北大核心
2012年第5期318-320,共3页
Journal of Environmental and Occupational Medicine
关键词
镍
致癌作用
实验病理
nickel
carcinogenicity
experimental pathology
