摘要
目的以健康人咽部菌群为基础，研究呼吸道感染经广谱抗生素治疗后咽部菌群密度的变化。方法采集180例健康人群与180例呼吸道感染未治疗的患者、呼吸道感染治疗后患者的咽拭子进行需氧培养、二氧化碳培养及厌氧培养，通过数据分析呼吸道感染未治疗患者和治疗后患者咽部茵群密度的分布和呼吸道菌群数量的变化。结果呼吸道感染未治疗患者的需氧菌密度为4．8752±0．9713，与健康组需氧菌密度5．1931±1．0917相比差异有统计学显著性意义（P〈0．01）；厌氧菌的密度为5．1476±0．9038，与健康组厌氧茵密度5．0917±0．9224相比差异无统计学意义（P〉0．05）；而呼吸道感染经5天三代头孢菌素治疗后患者的需氧菌密度为5．4579士1．0231，与健康组相比差异有统计学意义（P〈0．05）；厌氧菌密度为5．8963±0．7635．与健康组相比差异有统计学显著性意义（P〈0．001）。呼吸道感染未治疗患者组咽部的主要细菌甲型链球菌、奈瑟菌、消化链球菌的密度与健康组相比差异有统计学显著性意义（P〈0．001），微球菌的密度与健康组相比差异有统计学意义（P％0．01）．而葡萄球菌、类杆菌、韦荣球菌、梭杆菌的密度与健康组相比差异无统计学意义（P〉0．05）。结论呼吸道咽部菌群密度在健康人群之间保持着一定菌群种类和数量的稳定，但在呼吸道感染时菌群可失调，并随着广谱抗生素的应用会导致咽部菌群严重失调；呼吸道抗感染治疗应合理使用抗生素，避免严重导致呼吸遗茵群失调。
Objective Based on the research of healthy people＇s pharyngeal bacterium,to study the change of patient＇s pha- ryngeal flora density with respiratory tract infection before and after treated by broad-spectrum antibiotics. Methods Col- lected 180 throat swabs of healthy people and 180 patients with respiratory infections before and after treatment, to cultur bacterium under oxygen,carbon dioxide and anaerobic. Analysed the chang of bacterium amount and the distribution of re- spiratory tract infection before and after treatment. Results The number of the aerobes in patients with no treatment was 4. 875 2±0 971 3,and in healthy people group was 5. 1931±l. 091 7,so there was significant difference between these two groups （P〈0. 01）. The number of the anaerobic bacteria of these two groups was 5. 147 6±0. 903 8 and 5. 091 7i0. 922 4, respectively, so no significant difference existed between these two groups （P〉0. 05）. However, the number of the aerobes in patients treated by broad-spectrum antibiotics was 5. 457 9±1. 023 1,and the anaerobic bacteria was 5. 896 3±0. 763 5. THe was significant difference compared with health group（ P〈0. 05）. The number of Streptococcus viridans, Neisseria and Peptostreptococcus in the pharyngeal of patients with respiratory infection untreated was significant different to the healthy group （P〈0. 001）. Compared with the density of micrococcus in health group, there was difference （P〈0. 01）,and no obvious difference of Staphylococcus, Bacteroides, Veillonella and Fusobacterium density be found compared with the healthy group （P〉0. 05）. Conclusion The category and the amount of pharyngeal bacterium are stability, but disturbance will happen with respiratory infection. The application of broad-spectrum antibiotics will lead to serious pharyngeal dysbacte- riosis. The antibiotic：, treatment of respiratory infection should be reasonable in order to avoid the emerging of respiratory dysbacteriosis.
出处
《现代检验医学杂志》
CAS
2012年第2期41-43,共3页
Journal of Modern Laboratory Medicine
关键词
呼吸道感染及其治疗
咽部菌群密度
研究
respiratory infections and its treatment pharyngeal flora density research
