摘要
近年来，国内、国外人类疾病模型动物品种、品系繁多，遗传背景各异。国内基因修饰动物模型发展也很快，这些模型动物既有我们自己研发的，也有从国外引进的。建立动物模型的上游科研工作成绩突出，但宝贵的动物模型建立或引进后，由于种种原因导致动物断种、失去原有生物学特性的案例却屡见不鲜。从人类疾病模型动物的引种、保种、检疫隔离、饲养管理的特殊性等方面加强管理，可有效地控制和避免突变系出现自身修复，转基因动物的基因丢失，敲除基因动物基因复位等问题，从而达到保持其固有生物学特性的目的。
In recent years, many kinds of animal models of human diseases with different genetic background were developed. Some were established in China, others were imported from abroad. Precious were these animal models, their biological features could be lost for various reasons, for instance, reverse from mutation, lost of modified or constructed gene, etc. This study provided some suggestions for scientific management of the animal models to in terms of quarantine inspection, specific feeding method and methods to maintain gene stability, so as to preserve their biological features.
出处
《中华医学科研管理杂志》
2012年第2期129-130,F0004,共3页
Chinese Journal of Medical Science Research Management
基金
科技部“973”课题资助（2011CB933402）
