摘要
基因工程小鼠已成为生物医药领域重要的实验动物模型,且在国内外广泛交流。它既具有背景鼠的生理习性,也有其独特的生理特征,其繁育方案又不同于背景小鼠。因此,在使用并繁育基因工程小鼠之前,需要掌握必要的繁育知识和繁育技巧。该文旨在理论和实践的指导下,针对基因工程小鼠的繁育经验与同行进行交流,并帮助刚开始利用基因工程小鼠开始实验研究的实验人员掌握基本的相关知识。
Genetically modified mice have become important laboratory animal models in the field of biomedicine,and have been widely exchanged at home and abroad.Genetically modified mice both have the physiological characteristics of background mice and their unique physiological features,so their breeding scheme is different from that of background mice.Therefore,before using and breeding genetically modified mice,we need to acquire the requisite breeding knowledge and breeding skills.The purpose of this article is to exchange the breeding experience of genetically modified mice with peers under the guidance of the theories and practices and to help researchers who have just started using genetically modified mice to begin experimental researches to master basic relevant knowledge.
作者
彭旭
尹海林
PENG Xu;YIN Hailin(Experimental and Research Animal Institute,Sichuan University,Chengdu 610065,China)
出处
《实验科学与技术》
2021年第5期31-37,共7页
Experiment Science and Technology
基金
四川省科技基础条件平台项目(18PTDJ0027)
四川大学实验技术立项项目(20170211)。
关键词
基因工程小鼠
配种
繁育
建系
genetically modified mice
mating
breeding
establishment of germ line
