摘要
目的:研究阿司匹林维生素C泡腾片的处方及制备工艺。方法:主要以外观、可压性、泡腾效果和稳定性作为判断标准,对酸源、碱源、黏合剂等进行处方筛选,且对制备工艺进行考察。结果:阿司匹林维生素C泡腾片以枸橼酸为酸源,经过热处理的碳酸氢钠作为碱源,聚乙烯吡咯烷酮K30作为干燥黏合剂,采用干法制粒压片法制备。结论:制得的阿司匹林维生素C泡腾片外观完整光洁、泡腾效果好且稳定性高,有较高的开发价值。
Objective： To study the formulation and preparation technology of aspirin and vitamin C effervescent tablets. Methods： With appearance, compressibility, effervescent efficiency and stability as main criteria, the acid and alkali sources and adhesives were screened,and the preparation technology was investigated. Results： Besides polyvinyl pyrrolidone K30 used as dried adhesive, citric acid and heat-treated sodium bicarbonate were selected as the acid and alkali sources respectively for prep- aration of aspirin and vitamin C effervescent tablets by compressing dry granulation. Conclusion： Aspirin and vitamin C effer vescent tablets prepared by this method are intact and smooth,and have good effervescent efficiency, stability and value for fur- ther development.
出处
《药学服务与研究》
CAS
CSCD
2012年第2期129-131,共3页
Pharmaceutical Care and Research
关键词
阿司匹林
维生素C
泡腾片
处方
制备工艺
稳定性
aspirin
vitamin C effervescent tablets formulation preparation technology stability
