摘要
目的探讨血清N末端B型钠尿肽(NT-proBNP)在充血性心力衰竭(CHF)患者中的临床应用价值。方法胶体金法检测70例CHF患者的血清NT-proBNP水平,超声心动图测定左心室射血分数(LVEF)≤45%,20例健康人作为正常对照组。结果 CHF患者NYHAⅡ级、Ⅲ级、Ⅳ级组各组间NT-proBNP水平有统计学意义,且均高于对照组[分别为(1 210±45.7),(2 402±44.9),(3 809±67.1)nmol.L-1对(435±54.1)nmol.L-1,P<0.01]。血浆NT-proBNP水平与LVEF值呈负相关(r=-0.754,P<0.01)。血清NT-proBNP水平对CHF的诊断最适分界点为445 nmol.L-1时,其敏感性为90.5%,特异性为91.8%,阳性预测值为96.2%,阴性预测值为79.8%。结论血清NT-proBNP有助于心衰的诊断及其严重程度的评估,有重要的临床应用价值。
Objective To determine the value of the NT-proBNP in patients with chronic heart failure.Methods Colloidal Gold method was used to measure the levels of serum NT-proBNP in 70 patients who had been diagnosed CHF,and 20 healthy persons without CHF becoming control group,70 patients were diagnosed as chronic heart failure（CHF）whose left ventricular ejection（LVEF） being lower than 45%.Results The levels of serum NT-proBNP were much higher in CHF patients than those in the control group persons（P0.01）.There were signficant differentces of plasma NT-proBNP level among NYHA II,III,and IV in CHF patients[The values were（1 210±45.7）,（2 402±44.9） nmol·L-1,（3 809±67.1） nmol·L-1 vs（435±54.1） nmol·L-1,P0.01].The blood NT-proBNP level and the LVEF value were negatively related（r=-0.754,P0.01）.The cutoff value of NT-proBNP for diagnosis of CHF was 445 nmol·L-1.The sensitivity,specificity,positive predictive values and negative predictive values were 90.5%,91.8%,96.2%and 79.8%.Conclusion Plasma NT-proBNP level may be a valuable laboratory plasma marker for diagnosis of congestive heart failure.
出处
《安徽医药》
CAS
2012年第5期654-655,共2页
Anhui Medical and Pharmaceutical Journal
