期刊文献+

CD4^+CD25^+调节性T细胞在自身免疫性肝炎发病机制中的作用 被引量:6

Evolution of regulatory T cells in pathogenesis of autoimmune hepatitis
下载PDF
导出
摘要 自身免疫性肝炎(autoimmune hepatitis,AIH)是一种免疫介导的、慢性肝脏炎症性疾病,以高γ球蛋白血症、自身抗体阳性、肝组织学界面炎和免疫抑制治疗有效为特征[1]。尽管AIH的发病机制尚未完全阐明,但多项证据表明,遗传易感性、分子模拟学说及调节性T细胞(regulatory T cells。
出处 《临床肝胆病杂志》 CAS 2012年第5期332-334,342,共4页 Journal of Clinical Hepatology
基金 北京市自然科学基金资助项目(7111004) 国家自然科学基金资助项目(81102265)
关键词 自身免疫性肝炎 调节性T细胞 自身抗体 autoimmune hepatitis regulatory T cells autoantibody
  • 相关文献

参考文献2

二级参考文献53

  • 1Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association. 42 Dongsi Xidajie,Beijing 100710,China.慢性乙型肝炎防治指南[J].中华肝脏病杂志,2005,13(12):881-891. 被引量:1931
  • 2刘燕敏,闫惠平,檀玉芬,刘妍,冯霞,孔淑玲.抗可溶性肝抗原/肝胰抗原抗体阳性的肝病患者临床与实验室特征[J].中华肝脏病杂志,2005,13(12):927-929. 被引量:2
  • 3[1]Donaldson PT.Genetics in autoimmune hepatitis.Semin Liver Dis 2002;22:353-364 被引量:1
  • 4[2]Donaldson PT.Genetics of autoimmune and viral liver diseases;understanding the issues.J Hepatol 2004;41:327-332 被引量:1
  • 5[3]Czaja AJ,Donaldson PT.Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis.Immunol Rev 2000;174:250-259 被引量:1
  • 6[4]Ma Y,Bogdanos DP,Hussain MJ,Underhill J,Bansal S,Longhi MS,Cheeseman P,Mieli-Vergani G,Vergani D.Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2.Gastroenterology 2006;130:868-882 被引量:1
  • 7[5]Yokosawa S,Yoshizawa K,Ota M,Katsuyama Y,Kawa S,Ichijo T,Umemura T,Tanaka E,Kiyosawa K.A genomewide DNA microsatellite association study of Japanese patients with autoimmune hepatitis type 1.Hepatology 2007;45:384-390 被引量:1
  • 8[6]Simmonds MJ,Gough SC.Genetic insights into disease mechanisms of autoimmunity.Br Med Bull 2004;71:93-113 被引量:1
  • 9[7]Liston A,Lesage S,Gray DH,Boyd RL,Goodnow CC.Genetic lesions in T-cell tolerance and thresholds for autoimmunity.Immunol Rev 2005;204:87-101 被引量:1
  • 10[8]Lankisch TO,Strassburg CP,Debray D,Manns MP,Jacquemin E.Detection of autoimmune regulator gene mutations in children with type 2 autoimmune hepatitis and extrahepatic immune-mediated diseases.J Pediatr 2005;146:839-842 被引量:1

共引文献47

同被引文献64

  • 1谭友文,吴建成,於学军.熊去氧胆酸对Ⅰ型自身免疫性肝炎的疗效观察[J].临床肝胆病杂志,2004,20(5):283-284. 被引量:4
  • 2陈尉华,陆伦根.甘草酸在肝脏疾病治疗中的应用[J].国际消化病杂志,2006,26(2):106-109. 被引量:33
  • 3李蕴铷,王文冰,张黎颖,欧蔚妮,谢雯,魏来.甘草酸类药物治疗自身免疫性肝炎疗效分析[J].临床肝胆病杂志,2007,23(2):117-118. 被引量:20
  • 4Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma[ J ]. Lan- cet,2003,362 ( 9399 ) : 1907 - 1917. 被引量:1
  • 5Sakaguchi S,Sakaguchi N, Asano M,et al. Immunologic self - toler-ance maintained by activated T cells expressing IL -2 receptor alpha - chains ( CD25 ) : breakdown of a single mechanism of self - toler- ance causes various autoimmune diseases [ J]. J Immunol, 1995,155 (3) :1151 - 1164. 被引量:1
  • 6Yang ZZ, Novak AJ, Stenson MJ,et al. Intratumoral CDg CD25 regulatory T - cell - mediated suppression of infiltrating CD4 T ceils in B - cell non - Hodgkin lymphoma [ J ]. Blood, 2006,107 ( 9 ) : 3639 - 3646. 被引量:1
  • 7Liyanage UK, Moore TT, Joo HG,et al. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenviron -ment of pa- tients with pancreas or breast adenocarcinoma [ J ]. Immunol, 2004, 169:2756 - 2761. 被引量:1
  • 8Kawaida H, Kono K,Takahashi A,et al. Distribution of C D4 + C D25high regulatory T - cells in tumor - draining lymphnodes in patients with gastric cancer [ J ]. J Surg Res, 2005,124 ( 1 ) : 151 - 157. 被引量:1
  • 9Yukihiro S,Shunzaburo I,Ronald BH. Effects of cytokines on in vitro growth of tumor - infihrating lymphocytes obtained from human prima- ry and metastatic liver tumors [ J ]. Cancer Immunol Immunother, 1991,32(5) :280 -288. 被引量:1
  • 10Galon J,Costes A,Sanchez- Cabo F,et al. Type, density, and loca- tion of immune cells within human colorectal tumors predict clinicaloutcome [ J ]. Science,2006,313 ( 5795 ) : 1960 - 1964. 被引量:1

引证文献6

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部