摘要
目的探讨通心络对老年高血压合并糖尿病患者踝臂指数(ABI)的影响。方法入选119例老年高血压合并糖尿病患者,随机分为实验组62例和对照组57例,实验组在常规药物治疗基础上加服通心络,对照组仅予常规药物治疗,观察治疗前和治疗4、12周后ABI、血压(BP)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、超敏C反应蛋白(hs-CRP)、纤维蛋白原(FIB)等指标。结果治疗4周、12周后实验组ABI均较治疗前升高,BP均较治疗前下降,差异有统计学意义(P<0.05),对照组ABI、血压与治疗前比较差异无统计学意义(P>0.05);治疗4周后两组患者TC、LDL-C、FBG、HbA1c、hs-CRP、FIB与治疗前比较差异无统计学意义(P>0.05);治疗12周后实验组hs-CRP、FIB较治疗前显著下降,差异有统计学意义(P<0.05),对照组hs-CRP、FIB及两组的TC、LDL-C、FBG、HbA1c与治疗前比较差异无统计学意义(P>0.05)。结论通心络可以提高老年高血压合并糖尿病患者的踝臂指数,改善大动脉弹性,对炎症反应有一定的抑制作用,通心络对老年高血压合并糖尿病患者并发症的防治有重要意义。
Objective To investigate the effect of Tongxinluo on the ankle -brachial index（ABI） in elderly patients with hypertension and diabetes. Methods Totally 119 elderly patients with hypertension and diabetes were randomly divided into experimental group （ n = 62） and control group （ n = 57）. The experimental group received Tongxinluo based on the conventional drug therapy, and the control group only received conventional drug treatment. The ABI, blood pressure（BP）, total cholesterol （TC）, low density lipoprutein （LDL - C）, fasting blood glucose （FBG）, glycated hemoglobin （HbAlc） , high -sensitivity C -reactive protein （hs- CRP） and fibrinogen （FIB） were measured before and after treatment for 4 weeks, 12 weeks. Results The ABI was increased and BP was decreased in the experimental group compared with before treatment, and the difference was statistically significant （ P 〈 0.05 ） , The ABI and BP in the control group was of no significant difference compared with before treatment （P 〉 0.05）. The TC, LDL- C, FBG, HbAlc, hsCRP,FIB levels were of no statistical significance compared with before treatment for 4 weeks in both experimental and control groups （ P 〉 0. 05 ）. The hs - CRP and FIB levels were lower than before treatment for 12 weeks in the experimental group, and the difference was statisti- cally significant （P 〈 O. 05 ） , while there was no significantly difference in hs - CRP, FIB levels of the control group and in TC, LDL - C, FBG, HbA1 c levels of two groups （P 〉 O. 05）. Conclusion Tongxinluo can significantly improve the ankle - brachial index and the artery elasticity in elderly patients with hypertension and diabetes. It can inhibit the inflammatory response. Tongxinluo plays an important role on the prevention of complications in elderly patients with hv^ertension and diabetes.
出处
《医学研究杂志》
2012年第5期61-64,共4页
Journal of Medical Research
基金
浙江省老年医学重点建设学科群征集项目(2007ZJ006)
关键词
通心络
高血压
踝臂指数
Tongxinluo
Hypertension
Ankle - brachial index
