摘要
目的评估紫杉醇分别联合顺铂、卡铂、奈达铂对晚期肺鳞癌的近期疗效和毒副反应。方法 84例晚期肺鳞癌患者随机分为三组,每组28例,分别接受紫杉醇联合顺铂、紫杉醇联合卡铂、以及紫杉醇联合奈达铂方案化疗,每21天为一周期,两周期后评价疗效和毒副反应。结果紫杉醇联合顺铂、卡铂、奈达铂治疗晚期肺鳞癌有效率分别为57.14%、53.57%、28.57%,紫杉醇联合顺铂或卡铂治疗晚期肺鳞癌的有效率优于紫杉醇联合奈达铂,差异具有统计学意义(P<0.05),紫杉醇联合顺铂与其联合卡铂治疗晚期肺鳞癌的疗效相当,P>0.05。紫杉醇联合顺铂组恶心呕吐发生率最高,紫杉醇联合卡铂组血小板减少最明显,而紫杉醇联合奈达铂组则无明显毒副作用。结论紫杉醇联合顺铂或卡铂可作为治疗晚期肺鳞癌的一线治疗方案,而紫杉醇联合奈达铂因无明显毒副作用可能更适宜晚期肺鳞癌的年老体弱者化疗。
Objective To evaluate the efficacy and side effects of paclitaxel combined with cisplatin,carboplatin or nedaplatin in the treatment of advanced lung squamous cell cancer.Methods 83 advanced lung squamous cell cancer patients were randomly divided into three groups;each group had 28 cases which had been given paclitaxel combined with cisplatin,carboplatin and nedaplatin,respectively.Every 21 days is a cycle,and a clinical observation of short term effectiveness and adverse effects were carried out after two cycles.Results When given paclitaxel combined with cisplatin,carboplatin individually and nedaplatin individually,the overall response rate was 57.14%,53.57% and 28.57%,respectively.Compared to paclitaxel combined with nedaplatin,the response rate was better in the group of paclitaxel combined with cisplatin or carboplatin,and the statistical difference was significant（P0.05）.But there was no statistically significant difference in response rate between paclitaxel combined with cisplatin or carboplatin（P0.05）.At the same time,nausea and vomiting were more common in the group of paclitaxel combined with cisplatin,and thrombocytopenia occurred more frequently in the group of paclitaxel combined with carboplatin,but they were tolerable.However,there was no significant toxicity in the group of paclitaxel combined with nedaplatin.Conclusions Paclitaxel plus cisplatin or carboplatin regimens could become the standard chemotherapy in advanced lung squamous cell cancer.And paclitaxel combined with nedaplatin regimen may be more tolerable to the elderly and feeble patients with advanced lung squamous cell cancer.
出处
《临床肺科杂志》
2012年第6期1092-1093,共2页
Journal of Clinical Pulmonary Medicine
关键词
肺癌
鳞癌
紫杉醇
顺铂
卡铂
奈达铂
lung cancer
squamous cell cancer
paclitaxel
cisplatin
carboplatin
nedaplatin
