摘要
Th17细胞是一类与Th1、Th2及Treg细胞不同的新型效应CD4^+T细胞,研究已证实Th17细胞在感染、炎症、自身免疫性疾病及移植物抗宿主病中具有关键的致病作用。近来研究发现Th17细胞同样存在于肿瘤微环境中,并与炎症相关性肿瘤的发生有一定关系,但目前对Th17细胞在肿瘤微环境中的分化发育条件、免疫调控机制及具体功能效应尚不完全清楚本文将对Th17细胞及其相关细胞因子与肿瘤免疫相关性的研究进展作一简要综述。
Th17 cells have recently been classified as a new effector T-cell subset which is distinct from Th1, Th2 and Treg subsets. Since Th17 cells were found, studies confirmed that these cells had critical roles in infection, inflammation, autoimmune diseases, and graft versus host disease. Moreover, Th17 cells have been recently found in some human cancers, but the differentiation and development condition, regulation mechanisms and functional effects of Thl 7 cells remains controversial. This review summarizes recent findings regarding the correlation of Th17 cells and malignant tumor related cytokines with tumor immunity.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2012年第9期529-531,共3页
Chinese Journal of Clinical Oncology
基金
江苏省医学科研计划项目(编号:H201013)
江苏省研究生科研创新计划项目(编号:C×10B_054Z)
江苏省苏州市科教兴卫青年科技项目(编号:SWKQl004)资助~~
