摘要
耳聋是最为常见的健康问题之一,据估计全世界约有近十分之一人群有不同程度的听力下降〔1〕。2005年WHO估计双耳中到重度听力损失的有2.78亿。药物性聋是致聋的常见原因之一,3%～4%的发展中国家的成人和儿童以及相当数量发达国家的成人耳聋患者由药物（尤其氨基苷类抗生素）所致〔2〕。
Summary To present a summary of current knowledge regarding acute kanamycin sulfate-induced deafness in guinea pig, by reviewing the published literature. Animal model of acute deafness induced by a single dose of kana-mycin sulfate in combination with ethacrynic acid or furosemide in guinea pig was usually used to investigate the mechanism of cochlear cell degeneration. There were different time sequences of cell degeneration of spiral ganglion cell and hair cell in different studies. The findings may result from different doses, order of two drugs adminis-tration or time point chosen. There remains scope for further research in chronic kanamycin-induced deafness, which more replicates the type of exposure to people than acule deafness.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2012年第10期478-480,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
