摘要
目的 观察不同剂量异丙酚、利多卡因预处理对在体大鼠心肌再灌注心律失常的影响。方法 SD大鼠 5 6只 ,随机分为 7组。Sham组 :假手术组 ;NS组 :生理盐水组 ;L5组 :利多卡因 5mg·kg-1组 ;L10 组 :利多卡因 10mg·kg-1组 ;P30 0 组 :异丙酚 0 3mg·kg-1·min-1组 ;P10 0 0 组 :异丙酚 1mg·kg-1·min-1组 ;L5+P30 0 组 :利多卡因 5mg·kg-1+异丙酚0 3mg·kg-1·min-1组。生理盐水或利多卡因于缺血前 5min静脉注射 ( 30s内注射完 ) ,异丙酚于缺血前 5min静脉持续输注至缺血开始为止。结扎冠脉左前降支使相应心肌缺血 15min ,然后放松结扎线再灌注 10min(Sham组不结扎冠脉 )。实验中持续监测血流动力学变化 ,ECG肢体Ⅱ导联记录再灌期间室性心律失常的发生。结果 异丙酚大剂量降低MAP且减慢HR(P <0 0 5 ) ,利多卡因两剂量和两药小剂量联合应用可减慢心率 (P <0 0 5 ,P <0 0 1)。异丙酚或利多卡因可减少再灌注期间室早的发生 (P <0 0 1) ,降低室颤发生率 (P <0 0 5 ) ,并缩短室速的持续时间 (P <0 0 1)。大剂量异丙酚或利多卡因或两药小剂量联合用药还可降低室速的发生率 (P <0 0 1)。结论 异丙酚、利多卡因预处理可有效地减轻再灌注心律失常的发生 ,两药小剂量合用比两药大剂量单用对血流动力?
AIM To investigate the effects of propofol and lidocaine on myocardiol reperfusion arrhythmias in rats in vivo METHODS Fiftysix rats were randomly divided into seven groups group Ⅰ:sham;group Ⅱ:salinegroup Ⅲ:lidocaine 5 mg·kg -1 group Ⅳ:lidocaine 10 mg·kg -1 group Ⅴ:propofol 300 μg·kg -1 ·min -1 group Ⅵ: propofol 1000 μg·kg -1 ·min -1 group Ⅶ: lidocaine 5 mg·kg -1 + propofol 300 μg·kg -1 ·min -1 Five minutes before ischemia, saline or lidocaine was injected intraveneously(within 30 seconds)propofol was infused intraveneously till the onset of ischemia The left coronary artery was occluded using a silk suture for fifteen minutes Then the snare was loosened to achieve reperfusion for ten minutesMAP and HR were monitored throughout the experiment During reperfusion,ECGⅡ was recorded on a electro cardiograph at a chart speed of 25 mm/s RESULTS Compared with group Ⅰ, group Ⅵ decreased MAP、HR significantly(P<005) group Ⅲ and group Ⅶ could also decrease HR(P<005) group Ⅳ decreased HR extremely significantly(P<001)Compared with group Ⅱ,each group with drugs decreased the occurrences of ventricular premature beat (P<001),ventricular fibrillation(P<005) and shortened the duration of ventricular tachycardia(P<001) group Ⅲ、group Ⅵ、group Ⅶ could also decrease the occurrences of ventricular tachycardia(P<001) CONCLUSION Preconditioning with propofol or lidocaine could decrease the occurrences of myocardial reperfusion arrhythmias significantly The association of low dose of the two drugs generated little side effects on circulation dynamics,but could decrease the occurrence of the reperfusion arrhythmias as effectively as the high dose of either drug
出处
《中国药理学通报》
CAS
CSCD
北大核心
2000年第1期29-32,共4页
Chinese Pharmacological Bulletin
基金
卫生部科研基金资助课题!No9602
