摘要
目的 研究 β 环糊精与烷基钴肟类辅酶B12 模型物超分子化合物的合成。方法 烷基钴肟类辅酶B12 模型物通过还原性烷基化作用方法合成 ,所得产物与 β 环糊精在 50℃水溶液中溶解、过滤 ,滤液在2 5℃下静置 (避光 ) ,1周后得红棕色晶体。结果 产品用元素分析、紫外可见光谱表征 ,并利用低温四圆衍射仪进行了晶体结构分析 ,证实了烷基钴肟与 β 环糊精超分子化合物的形成。 结论 β 环糊精与烷基钴肟形成 1∶1包合物 ,其中 ,烷基钴肟的烷基包结在β 环糊精的疏水腔内 ,平面配体位于 β 环糊精的较大开口端。
Objective The synthesis of supramolecules of alkylcobaloxime Coenzyme B 12 models with β cyclodextrine.Methods The coenzyme B 12 models of alkylcobaloxime were synthesized by standard reductive alkylation methods.Alkylcobaloxime and β cyclodextrine were dissolved in water at 50℃.The resulting solution was filtered and the filtrate was stored at 25℃ in the dark.Within one week,red brown crystals precipitated.Result The products were characterized by elementary analysis、UV visible、X ray structure analysis.Then,it was proved that β cyclodextrine and alkylcobaloxime form a kind of supramolecules.Conclusion β cyclodextrine and alkylcobaloxime form a kind of 1∶1 inclusion complexes.Besides,the alkyl group of β cyclodextrine and the equatorical ligand was located near the wider opening.
出处
《济宁医学院学报》
2000年第1期34-35,共2页
Journal of Jining Medical University
