摘要
目的为Au（Ⅲ）配合物在医用和药用的有机合成反应路径提供有利的依据。方法分光光度法研究了在288.2~308.2 K的酸性介质中,Au（Ⅲ）配合物与丙二酸（MAH2）的氧化还原反应动力学及其机理。结果反应对Au（Ⅲ）和丙二酸（MAH2）均为一级;在保持准一级反应条件（[MAH2]o〉〉[Au（Ⅲ）]o）下,其表观速率常数随[H＋]增大而减少,随[Br-]增大而增大;离子强度I的增加使表观速率常数随之增大,对反应有正盐效应。结论根据实验现象提出了可能的反应机理并求出了速控步骤的速率常数及活化参数。
Objective It provided a strong basis for the path of organic synthesis in the medical and pharmaceutical.Methods The kinetics of reduction of tetrabromaurate（Ⅲ） ion by malonic acid（MAH2） has been spectrophotometrically studied in acid medium at different temperatures（288.2-308.2 K）.Results Under pseudo first-order conditions（[MAH2]o [Au（Ⅲ）]o）,the experimental results showed that the redox reaction was first order in [Au（Ⅲ）] and malonic acid（MAH2）.It was found that the rate constant kobsincreased with the increase of [H＋],while bromine ions was contrary.There was positive salt effect.conclusion Based on the experimental results,a probable reaction mechanism of oxidation was proposed.The activation parameters along with the rate constants of rate-determined step were calculated and thermodynamic quantities were also determined.
出处
《医学研究与教育》
CAS
2012年第2期72-77,共6页
Medical Research and Education
基金
河北省科技厅应用基础专项项目(09965120D)
保定市科学研究与发展计划项目(10ZF063)
