摘要
合成了两个系列含有三苯锗丙酰基的α－氨基膦酸酯类化合物，研究了空阻大的α－氨基膦酸酯与β－三苯锗丙酸的缩合方法、反应条件及反应机理．生物活性测定结果表明，这类衍生物与相应的α－氨基膦酸衍生物相比有显著抗癌活性和抗烟草病毒活性。
In this paper,two series of N-(β-triphenylgermanyl)propionyl-α-aminomethylphosphonates have been synthesized and both conditions and mechanism of the condensation reaction of sterically hindered α-aminomethylphosphonate with βtriphenylgermanyl propionic acid were studied. Preliminary bioassays indicate that the title compounds compared with corresponding α-amino-methylphosphonates have more significant antitumor and anti-TMV properties.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1995年第6期892-895,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金资助课题
关键词
Α-氨基膦酸酯
β-三苯锗丙酸
缩合反应
抗癌活性
结构鉴定
α-Amino-methylphosphonate
β-Triphenylgermanyl propionic acid
Condensation reaction
Antitumor activity
Structure confirmation
