摘要
目的探讨右美托咪啶预先镇痛用于预防全麻苏醒期躁动与术后镇痛的安全性及有效性。方法食管癌切除术患者160例，随机分为右美托咪啶组（D组）和对照组（C组）。前组切皮前静脉输注右美托咪啶0．75μg·kg^-1；C组同时间静脉注射0．9％生理盐水20ml。观察术后不同时点的Riker镇痛-躁动评分（SAS）及VAS评分。结果术后各时点D组SAS与VAS评分均低于C组（P〈0．01），D组躁动发生率低于C组（P〈0．01）。D组无术后使用镇痛药者，C组12例需给予曲马朵。结论右美托咪啶预先镇痛可有效预防全麻患者术后躁动，提高术后镇痛效果。
Objective To explore the safety and efficacy of preemptive analgesia with dexmedetomidine on preventing emergence agitation and postoperative analgesia. Methods One hundred and sixty patients underwent esophageal cancer radical surgery were randomly divided into two groups： the dexmedetomidine group （group D） and control group （group C）. In group D patients were given intravenous infusion of dexmedetomidine 0.75 μg·kg^-1 before skin incision. In group C patients were given intravenously normal saline 0.9% 20 ml. Riker sedation agitation scale（SAS） and VAS were recorded at different times after operation. Results SAS and VAS in group D were lower than those in group C （P〈0.01）. The incidence of agitation in group D was lower than that in group C （P〈0.01）. No patients were administered analgesics postoperatively in group D, however, in group C 12 patients were given tramadol. Conclusion Dexmedetomidine preemptive analgesia can prevent effectively postoperative agitation in patients with general anesthesia and improve the efficacy of postoperative analgesia.
出处
《实用疼痛学杂志》
2012年第1期38-40,共3页
Pain Clinic Journal
关键词
右美托咪啶
躁动
预先镇痛
麻醉恢复期
Dexmedetomidine
Psychomotor agitation
Preemptive analgesiai Anesthesia recovery period
