摘要
目的综述胰岛素近年来鼻黏膜给药的相关信息。方法查阅国内外相关文献36篇,进行相关分析、归纳和总结。结果综述出鼻黏膜给药的特点以及提高鼻黏膜生物利用度的诸多方法。在胰岛素制剂中加入安全高效的吸收促进剂或水不溶性粉末将会很大程度上提高其生物利用度。结论胰岛素鼻黏膜给药在药学领域将会有广阔的发展前景。
Objective To review the new administration routes of insulin and the development of intranasal delivery system.Methods According to thirty-six recent relevant literatures,the new routes and the development of intranasal delivery system of insulin were summarized.The new routes of insulin administration,the characteristics of intranasal delivery and some strategies to improve the bioavailability of insulin after nasal administration were summarized.Results It seems that the addition of safe absorption enhancers or water-insoluble powders into insulin formulation can dramatically improve the bioavailability of insulin after nasal administration.Conclusions The intranasal administration of insulin in the pharmaceutical field is promising.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2012年第4期312-319,共8页
Journal of Shenyang Pharmaceutical University
关键词
胰岛素
鼻黏膜给药
吸收促进剂
水不溶性粉末
insulin
intranasal administration
absorption enhancer
water-insoluble powder
