摘要
目的介绍胰岛素肺部给药系统的研究进展。方法综述了肺部给药机制、胰岛素吸入制剂/装置、药动学和药效学特点、临床应用等研究内容。结果与结论胰岛素肺部给药系统的发展用以补充和/或替代皮下注射,可能是一种有效方法,使患者获得更好地糖尿病治疗结果。
OBJECTIVE To introduce the research and development of insulin formulations for pulmonary delivery system.METHODS This review will discuss the mechanism of pulmonary delivery,inhaled insulin formulations/devices,pharmacokinetics and pharmacodynamics,the efficacy and safety of inhaled insulin in the treatment of diabetes. RESULTS and CONCLUSION The development of pulmonary insulin delivery to supplement and/or replace subcutaneous insulin injections may be an effective alternative,allowing patients to achieve intensive diabetes management.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2008年第z1期609-613,共5页
Chinese Journal of Modern Applied Pharmacy
关键词
吸入胰岛素
肺部给药
inhaled insulin
pulmonary delivery
