摘要
目的:探讨血清CA19-9及CA125测定对子宫内膜异位症(EMs)的诊断价值。方法:采用放射免疫法测定55例EMs患者血清CA19-9及CA125水平,并与同期门诊健康妇女(对照组)进行比较。结果:EMs组及对照组血清CA19-9和CA125检测值的中位数及阳性率分别为27.81 U/mL、43.6%,11.78 U/mL、0和24.2 U/mL、36.3%,9.02 U/mL、4.0%。两组间差异均有统计学意义(均P<0.05)。中重度(Ⅲ～Ⅳ期)EMs患者与轻度(Ⅰ～Ⅱ期)患者血清CA19-9和CA125中位数和阳性率分别为42.38 U/mL、57.9%,17.36 U/mL、11.8%和34.75 U/mL、50.0%,15.3U/mL、5.9%,不同分期间差异有统计学意义(均P<0.05)。血清CA19-9和CA125诊断EMs的敏感度、特异度及准确度分别为43.6%、100%、61.25%及36.3%、96.0%、55.0%。结论:血清CA125和CA19-9在EMs患者中均有明显升高,测定两种血清标记物水平可协助EMs的诊断;两者血清水平与EMs患者病情程度有关。
Objective：To investigate the diagnostic values of CA19-9 and CA125 in the serum for endometriosis. Methods ：CA19-9 and CA125 serum levels were determined with RIA in 55 patients with endometriosis and 25 control healthy women. Results ：the mean serum levels and positive rate of CA19-9 and CA125 for endometriosis and controls are 27.81 U/mL,43.6%, 11.78 U/mL, 0 and 24.2 U/mL,36.3%, 9.02 U/mL, 4.0%, respectively. There is significant difference between the measure result and positive rate of CA19-9 and CA125 for endometriosis group and control （P〈0.05）. The mean serum levels of CA19-9 and CA 125 in patients at stages 111-1V and I ~ 1I , according to the Revised American Fertility Society（R-AFS） classification,are 42.38 U/mL,57.9%, 17.36 U/mL, 11.8% and 34.75 U/mL,50.0%, 15.3 U/mL,5.9%. The difference of the mean serum levels and positive rate between the groups is significant （P〈0.05）. The sensitivity, specificity and accuracy of CA19-9 and CA125 serum levels in diagnosis of endometriosis are 43.6%, 100% and 61.25% ;36.3%, 96.0% and 55.0%,respectively. Conclnsions：Measure the levels of CA19-9 and CA125 in serum can raise the sensitivity of diagnosis for endometriosis. The predictive values of CA 19-9 and CA 125 seem high only to predict severe （stages Ⅲ and Ⅳ ） disease.
出处
《国际妇产科学杂志》
CAS
2012年第2期194-195,210,共3页
Journal of International Obstetrics and Gynecology
