摘要
女性生殖器官恶性肿瘤中,卵巢癌病死率居第1位。尽管手术及化疗技术有所改进,但是复发率和耐药性仍居高不下。靶向治疗成为治疗卵巢癌的一种有效手段。靶向治疗能够增强对肿瘤细胞的杀伤力,减少对正常组织的损伤,目前逐步应用于卵巢癌的临床治疗,且与传统治疗方法相比显示出优势。从分子靶向药物治疗和靶向基因治疗两个方面对近年来卵巢癌靶向治疗的研究现况、治疗应用进行总结以及展望。
Ovarian cancer is the leading cause of death from gynecological cancer. Although some advances in surgical and chemotherapeutic strategies have been made, there still remains a significant risk for recurrence and resistance to therapy. Targeted therapy become a effective method against ovarian cancer, which could improve the ability to kill cancer cells and to reduce the damage to normal tissues. Targeted therapy has gradually applied to clinical treatment and shown an advantage to tranditional ones. This paper review targeted therapies in ovarian cancer in form of molecular targeted and gene targeted, in order to know about the current situation and the prospective research of the treatment in ovarian cancer.
出处
《国际妇产科学杂志》
CAS
2012年第2期152-157,共6页
Journal of International Obstetrics and Gynecology
关键词
卵巢肿瘤
抗体
单克隆
基因疗法
遗传载体
信号传导
分子靶向治疗
PARP抑制剂
Ovarian neoplasmas
Antibodies,monoclonal
Gene therapy
Genetic vectors
Signal transduetion
Molecular targeted therapy
PARP inhibitor
