摘要
目的:探讨卒中后抑郁(PSD)患者载脂蛋白E(ApoE)水平特点,为PSD的诊断提供新的客观依据。方法:采用实时荧光定量PCR技术和酶联免疫吸附法(ELISA)检测PSD患者及卒中后非抑郁患者ApoE水平。结果:PSD组ApoE基因mRNA表达量低于卒中组,差异具有统计学意义(P<0.01);PSD组血清ApoE水平高于卒中组,差异具有统计学意义(P<0.05)。结论:PSD患者外周血ApoE基因mRNA表达和血清ApoE水平与卒中非抑郁患者不同。
Objective：To study the level of apolipoprotein E（ApoE） in post-stroke depression（PSD）patients,in order to provide new objective basis for clinical diagnosis in PSD.Method：Detected the levels of ApoE by real-time PCR and enzyme linked immunosorbent assays（ELISA） technique with PSD patients and brain stroke patients.Results：The expression quantity of ApoE gene mRNA in PSD group is less than brain stroke group and there was significant difference（P〈0.01）.The serum level of ApoE in PSD group is higher than that with brain stroke group and there was significant difference（P〈0.05）.Conclusion：The expression of ApoE gene mRNA and serum protein level is different between post-stroke depression group and brain stroke group,it can be considered in dragnosts and treatment of PSD patients.
出处
《临床精神医学杂志》
2012年第2期111-112,共2页
Journal of Clinical Psychiatry
基金
河南省卫生厅医学科技攻关项目(200803083)
新乡医学院高学历资助项目(08BSSKYQD-003)
关键词
卒中后抑郁
载脂蛋白E
脑卒中
post-stroke depression； apolipoprotein E； brain stroke
