摘要
目的:探讨在肠外营养的基础上2种不同喂养添加量对早产儿瘦素(Leptin)、胰岛素样生长因子-1(Insulin-like growthfactor-1,IGF-1)表达水平的影响。方法:将64例收住ICU的早产儿在肠外营养基础上,第1天和第2天以5 ml/(kg.d)的乳量喂养,第3天以15 ml/(kg.d)的乳量喂养,72 h后使用随机数字表分为试验组31例和对照组33例。试验组以30 ml/(kg.d)的乳量逐日递增,对照组以20 ml/(kg.d)的乳量逐日递增,直至达到完全肠内喂养量150 ml/(kg.d)。喂养期间每天测量2组早产儿的体重、每周测量其身长、头围;喂养后第10天测血清Leptin,IGF-1的表达水平。结果:试验组1月时的体重明显高于对照组(P<0.05),且出生后第10天的血清Leptin、IGF-1表达水平均明显高于对照组(P<0.05)。结论:肠外营养联合30 ml/(kg.d)的肠内喂养添加量可以提高早产儿血清中Leptin、IGF-1的表达水平,而有利于早产儿的生长发育。
Objective：To explore the influence of two different feedings,on the basis of parenteral nutrition,on the premature infants＇ Leptin and Insulin-like growth factor-1（IGF-1）expression levels.Methods：On the first and second day,64 premature infants in ICU,on the basis of parenteral nutrition,were fed with 5 ml/（kg·d） milk each day,and were fed with 15 ml/（kg·d） milk on the third day.Then 31 of them were put into test group and 33 into control group by using random number table 72 hours later.The daily increment of feeding in test group was 30 ml/（kg·d） milk,and the increment was 20 ml/（kg·d） milk in the control,until the feedings of intestine reached 150 ml/（kg·d）.All the infants＇ everyday weight and weekly height and head circumference were measured during the feeding;10 days later,the expression levels of Leptin and IGF-1 in blood serum were tested.Results：After one month,infants＇ weight in the test group was significantly higher than that of control group（P0.05）.The expression levels of Leptin and IGF-1 in blood serum in the test group were also higher than those of control group 10 days after the infants were born（P0.05）.Conclusion：Parenteral nutrition mixed with an increasing amount of 30 ml/（kg·d） of enteral feeding can improve the expression levels of Leptin and IGF-1 in blood serum of preterm infants,and is conducive to the their growth.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2012年第3期248-251,共4页
Journal of Chongqing Medical University
关键词
肠外营养
肠内喂养
早产儿
瘦素
胰岛素样生长因子-1
parenteral nutrition（PN）
enteral nutrition（EN）
premature children
leptin
insulin-like growth factor-1（IGF-l）
